Review: could Acetaminophen cause Angioedema?


Angioedema is found among people who take Acetaminophen, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Aspirin, and have Hypertension . We study 72,264 people who have side effects while taking Acetaminophen from FDA and social media. Among them, 266 have Angioedema. Find out below who they are, when they have Angioedema and more.

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Acetaminophen has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Acetaminophen 74,921 users)


Angioedema (rapid swelling of the dermis) has been reported by people with drug hypersensitivity, renal failure acute, joint pain, chest pain, fatigue (latest reports from 13,230 Angioedema patients).

On Aug, 25, 2016

72,264 people reported to have side effects when taking Acetaminophen.
Among them, 266 people (0.37%) have Angioedema

Number of reports submitted per year:

Could Acetaminophen cause Angioedema?

Time on Acetaminophen when people have Angioedema *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Angioedema when taking Acetaminophen *:

  • female: 52.87 %
  • male: 47.13 %

Age of people who have Angioedema when taking Acetaminophen *:

  • 0-1: 0.86 %
  • 2-9: 5.6 %
  • 10-19: 4.74 %
  • 20-29: 6.03 %
  • 30-39: 12.5 %
  • 40-49: 6.9 %
  • 50-59: 16.38 %
  • 60+: 46.98 %

Top conditions involved for these people *:

  • Hypertension (38 people)
  • Pain (18 people)
  • Hot Flush (15 people)
  • Breast Cancer (15 people)
  • Osteoporosis (7 people)

Top co-used drugs for these people *:

  • Aspirin (47 people)
  • Omeprazole (38 people)
  • Ibuprofen (32 people)
  • Simvastatin (29 people)
  • Lisinopril (25 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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