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Review: could Acetaminophen cause Withdrawal syndrome?

Summary: Withdrawal syndrome could be caused by Acetaminophen, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Lyrica, and have Pain.

We study 69,410 people who have side effects while taking Acetaminophen from FDA and social media. Among them, 96 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.

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Acetaminophen

Acetaminophen (latest outcomes from 70,671 users) has active ingredients of acetaminophen. It is often used in pain.

Withdrawal syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) (latest reports from 55,487 patients) has been reported by people with depression, pain, acupuncture and pain, stress and anxiety, muscle spasticity.

On Apr, 8, 2014: 69,392 people reported to have side effects when taking Acetaminophen. Among them, 96 people (0.14%) have Withdrawal Syndrome. They amount to 0.17% of all the 55,118 people who have Withdrawal Syndrome on eHealthMe.

Trend of Withdrawal syndrome in Acetaminophen reports

Time on Acetaminophen when people have Withdrawal syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Withdrawal syndrome0.00%75.00%0.00%25.00%0.00%0.00%0.00%

Gender of people who have Withdrawal syndrome when taking Acetaminophen * :

FemaleMale
Withdrawal syndrome55.21%44.79%

Age of people who have Withdrawal syndrome when taking Acetaminophen * :

0-12-910-1920-2930-3940-4950-5960+
Withdrawal syndrome0.00%0.00%9.76%1.22%12.20%25.61%6.10%45.12%

Severity of Withdrawal syndrome when taking Acetaminophen ** :

n/a

How people recovered from Withdrawal syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pain (23 people, 23.96%)
  2. Anxiety (10 people, 10.42%)
  3. Insomnia (9 people, 9.38%)
  4. Suicidal ideation (8 people, 8.33%)
  5. Depression (7 people, 7.29%)

Top co-used drugs for these people * :

  1. Lyrica (18 people, 18.75%)
  2. Ibuprofen (16 people, 16.67%)
  3. Paroxetine hcl (15 people, 15.62%)
  4. Omeprazole (12 people, 12.50%)
  5. Tramadol hcl (11 people, 11.46%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Acetaminophen, Withdrawal syndrome

You can also:

On eHealthMe, Acetaminophen (acetaminophen) is often used for pain. Find out below the conditions Acetaminophen is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Acetaminophen used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (4 months ago):

  • Previously using and recently withdrawn from the following medications: morphine (replaced by suboxone) moclobemide and duloxetine (replaced wita time of intense personal crisis and during an emotional breakdown. Some symptoms existed prior to change in medication, some are new and some have been worsening rapidly on a daily basis.

    Reply

  • From this study (4 months ago):

  • Previously using and recently withdrawn from the following medications: morphine (replaced by suboxone) moclobemide and duloxetine (replaced with mirtazipine) and recently tapered off diazepam against will and against medical advice from GP in order to meet local suboxone prescribing regulations. All this occurred during a time of intense personal crisis and during an emotional breakdown. Some of the symptoms had been present prior to drug changes and some manifested afterward or while others seemingly became aggravated by the recent changes in (cessation of old and beginning of new) medication. In any case, many of the symptoms seem to be worsening rapidly on a daily basis.

    Reply

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More questions for: Acetaminophen, Withdrawal syndrome

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