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Review: could Alli cause Headache?

Summary: Headache is found among people who take Alli, especially for people who are female, 40-49 old, have been taking the drug for < 1 month, also take medication Unspecified medication, and have Weight loss. We study 15,869 people who have side effects while taking Alli from FDA and social media. Among them, 964 have Headache. Find out below who they are, when they have Headache and more.

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Alli has active ingredients of orlistat. It is often used in obesity. (latest outcomes from 16,192 Alli users)


Headache (pain in head) has been reported by people with multiple sclerosis, depression, high blood pressure, rheumatoid arthritis, osteoporosis. (latest reports from 202,450 Headache patients)

On May, 10, 2015: 15,869 people reported to have side effects when taking Alli. Among them, 964 people (6.07%) have Headache.

Trend of Headache in Alli reports

Time on Alli when people have Headache * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Headache when taking Alli * :


Age of people who have Headache when taking Alli * :


Severity of Headache when taking Alli ** :


How people recovered from Headache ** :


Top conditions involved for these people * :

  1. Weight loss diet (136 people, 14.11%)
  2. Weight control (9 people, 0.93%)
  3. Weight decreased (6 people, 0.62%)
  4. Vitamin supplementation (4 people, 0.41%)
  5. Fibromyalgia (3 people, 0.31%)

Top co-used drugs for these people * :

  1. Unspecified medication (33 people, 3.42%)
  2. Multi-vitamin (12 people, 1.24%)
  3. Wellbutrin (11 people, 1.14%)
  4. Cough syrup with codeine (11 people, 1.14%)
  5. Bc (11 people, 1.14%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of alli and headache on

Do you have Headache while taking Alli?


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- support group for people who take Alli and have Headache
- support group for people who take Alli
- support group for people who have Headache

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Comments from related studies:

  • From this study (1 month ago):

  • I am considered "morbidly obese" but until recently had been a healthy obese

    Under doctor's supervision have been on aggressive diet for 6months and have lost 50lbs - but have seen an increase in the size of my thighs and abdomen

    Have also been treated for lymphedema of the lower leg - which started with the trauma of an infected insect bite, on the same leg that had two ankle sprains. With manual lymph drainage and compression stockings, the lower legs have become under control.

    The swelling has moved north - into the thighs and abdomen. so much so, the pressure at my knee caused a hyper extension of the joint that I have been recovering from for almost a year.

    Related to this - my belly button is now protruding and looking potentially like it's herniated....

    I've also had a row of lesions on lower abdomen - that haven't been active since last summer. Until last Thurs - when one reactivate, swelled, and eventually drained Saturday.

    Had lots of gas Saturday night. Then on Sunday it felt like there was pressure on the bladder - frequent desire to urinate without volume ongoing for 3 days.

    The pressure on my bladder - is typical near the beginning of a period - but usually for a part day when I first start to menstruate. I'm in the middle of my cycle and not due to menstruate for 2 more weeks.

    Have had regular bloodwork and urinalysis - it's not a UTI or Bladder Infection...normal white cell count.

    Am concerned about the possibility of Endometriosis and wondering if it could be connected to the lymphedema (or at least if both conditions are escalating one another).

    Could any of the medicines I'm taking be exaggerating this?


  • From this study (1 month ago):

  • rapid weight gain withing 4 months or so


  • From this study (1 month ago):

  • Claudia on Mar, 25, 2015:

    I am female 58 yrs old and have been taking Xarelto for 4 months. I started getting headaches one month after beginning the drug treatment for a DVT. The headaches are daily and severe. I went to the hospital where they did a Cat scan, MRI, ultrasound of my veins, all to no avail. There's no brain bleed but maybe I have muscle strain in my neck. Thank you and thousands of dollars later. My Doctor has tried some drug therapy, chiropractor, and now I am trying deep tissue massage. If this is a side effect that may go away in another month or two I may be able to deal with this. Splitting the 20mg 2x daily is something I will talk to my doctor about. I do not want to go off this drug if this is temporary. Anyone have this experience?


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