Review: could Amitriptyline Hydrochloride cause Chronic Fatigue Syndrome?


Chronic fatigue syndrome is found among people who take Amitriptyline Hydrochloride, especially for people who are female, 50-59 old , have been taking the drug for 2 - 5 years, also take medication Atenolol, and have Fibromyalgia . We study 6,136 people who have side effects while taking Amitriptyline hydrochloride from FDA and social media. Among them, 15 have Chronic fatigue syndrome. Find out below who they are, when they have Chronic fatigue syndrome and more.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,380 users)

Chronic Fatigue Syndrome

Chronic fatigue syndrome (disorder that causes extreme fatigue) has been reported by people with pain, drug ineffective, insomnia, memory loss, fatigue (latest reports from 2,580 Chronic fatigue syndrome patients).

On Aug, 29, 2016

6,136 people reported to have side effects when taking Amitriptyline Hydrochloride.
Among them, 15 people (0.24%) have Chronic Fatigue Syndrome

Number of reports submitted per year:

Could Amitriptyline hydrochloride cause Chronic fatigue syndrome?

Time on Amitriptyline Hydrochloride when people have Chronic Fatigue Syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 8.33 %
  • 6 - 12 months: 16.67 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 58.33 %
  • 5 - 10 years: 8.33 %
  • 10+ years: 8.33 %

Gender of people who have Chronic Fatigue Syndrome when taking Amitriptyline Hydrochloride *:

  • female: 66.67 %
  • male: 33.33 %

Age of people who have Chronic Fatigue Syndrome when taking Amitriptyline Hydrochloride *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 13.33 %
  • 30-39: 13.33 %
  • 40-49: 33.33 %
  • 50-59: 40.0 %
  • 60+: 0.0 %

Severity if Chronic Fatigue Syndrome when taking Amitriptyline Hydrochloride **:

  • least: 0.0 %
  • moderate: 20 %
  • severe: 70 %
  • most severe: 10 %

How people recovered from Chronic Fatigue Syndrome **:

  • while on drug: 0.0 %
  • after off the drug: 12.5 %
  • not yet: 87.5 %

Top conditions involved for these people *:

  • Fibromyalgia (15 people)
  • Hypertension (12 people)
  • Hypothyroidism (9 people)
  • Headache (9 people)
  • Exhaustion, Fatigue, Lethargy, Tiredness, Weariness (9 people)

Top co-used drugs for these people *:

  • Tapentadol Hydrochloride (9 people)
  • Paracetamol (9 people)
  • Levothyroxine Sodium (9 people)
  • Codeine (9 people)
  • Atenolol (9 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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