Review: could Amitriptyline Hydrochloride cause Fatigue?


Fatigue is found among people who take Amitriptyline Hydrochloride, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Fosamax, and have Depression . We study 6,136 people who have side effects while taking Amitriptyline hydrochloride from FDA and social media. Among them, 389 have Fatigue. Find out below who they are, when they have Fatigue and more.

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Amitriptyline Hydrochloride

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,238 users)


Fatigue (feeling of tiredness) has been reported by people with breathing difficulty, pain, weakness, insomnia, stress and anxiety (latest reports from 231,716 Fatigue patients).

On Aug, 19, 2016

6,136 people reported to have side effects when taking Amitriptyline Hydrochloride.
Among them, 389 people (6.34%) have Fatigue

Number of reports submitted per year:

Could Amitriptyline hydrochloride cause Fatigue?

Time on Amitriptyline Hydrochloride when people have Fatigue *:

  • < 1 month: 23.17 %
  • 1 - 6 months: 13.41 %
  • 6 - 12 months: 12.2 %
  • 1 - 2 years: 12.2 %
  • 2 - 5 years: 15.85 %
  • 5 - 10 years: 15.85 %
  • 10+ years: 7.32 %

Gender of people who have Fatigue when taking Amitriptyline Hydrochloride *:

  • female: 75.33 %
  • male: 24.67 %

Age of people who have Fatigue when taking Amitriptyline Hydrochloride *:

  • 0-1: 0.57 %
  • 2-9: 0.28 %
  • 10-19: 1.42 %
  • 20-29: 3.97 %
  • 30-39: 8.5 %
  • 40-49: 17.85 %
  • 50-59: 28.05 %
  • 60+: 39.38 %

Severity if Fatigue when taking Amitriptyline Hydrochloride **:

  • least: 1.79 %
  • moderate: 41.07 %
  • severe: 42.86 %
  • most severe: 14.29 %

How people recovered from Fatigue **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Osteoporosis (59 people)
  • Depression (59 people)
  • Hypertension (41 people)
  • Osteopenia (36 people)
  • Sleep Disorder (29 people)

Top co-used drugs for these people *:

  • Fosamax (69 people)
  • Gabapentin (43 people)
  • Synthroid (37 people)
  • Omeprazole (34 people)
  • Celebrex (34 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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