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Review: could Arava cause Breast cancer?

Summary: Breast cancer is found among people who take Arava, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Celebrex, and have Rheumatoid arthritis. We study 16,221 people who have side effects while taking Arava from FDA and social media. Among them, 85 have Breast cancer. Find out below who they are, when they have Breast cancer and more.

You are not alone: join a support group for people who take Arava and have Breast cancer >>>

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Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. (latest outcomes from 16,332 Arava users)

Breast cancer

Breast cancer has been reported by people with hormone replacement therapy, multiple sclerosis, rheumatoid arthritis, menopausal symptoms, osteoporosis. (latest reports from 77,363 Breast cancer patients)

On May, 15, 2015: 16,221 people reported to have side effects when taking Arava. Among them, 85 people (0.52%) have Breast Cancer.

Trend of Breast cancer in Arava reports

Time on Arava when people have Breast cancer * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Breast cancer19.23%23.08%7.69%11.54%26.92%11.54%0.00%

Gender of people who have Breast cancer when taking Arava * :

Breast cancer100.00%0.00%

Age of people who have Breast cancer when taking Arava * :

Breast cancer0.00%21.05%0.00%0.00%0.00%6.14%23.68%49.12%

Severity of Breast cancer when taking Arava ** :


How people recovered from Breast cancer ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (85 people, 100.00%)
  2. Hormone replacement therapy (10 people, 11.76%)
  3. Hypertension (5 people, 5.88%)
  4. Osteoporosis (5 people, 5.88%)
  5. Osteopenia (3 people, 3.53%)

Top co-used drugs for these people * :

  1. Celebrex (63 people, 74.12%)
  2. Aldactone (48 people, 56.47%)
  3. Bumetanide (48 people, 56.47%)
  4. Methotrexate (27 people, 31.76%)
  5. Enbrel (27 people, 31.76%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of arava and breast cancer on

Do you have Breast Cancer while taking Arava?


You are not alone! Join a support group on :
- support group for people who take Arava and have Breast Cancer
- support group for people who take Arava
- support group for people who have Breast Cancer

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Comments from related studies:

  • From this study (3 months ago):

  • jcolville on Mar, 2, 2015:

    My aunt had endometriosis. I know she was given lupron. Not sure how many rounds. I know she ended up having a hysterectomy (total) and started HRT. She waa diagnosed with breaat cancer quickly (maybe 1-6 months). I really dont know. i know my mom told me HRT

    but she said the dr said happened very quickly

    And think may have had before. But we dont know.

    I took lupron in 2006 for endometriosis. I had severe, adverse reactions the very next day. I was in agony. My bones and pelvic abdominal pain was the worst in my life. My BP was aky high and went to ER twice. I also had a seizure and fainted. I did end up having hysterectomy in 2013. I kept ovaries because my mom told me my aunt got cancer from HRT. My mom doesnt have endo but my aunt did. She passed away in 2010. I am learning contrary to what drs have told me. Other women suffer from bone/joint/muscle pain, migraines. What if lupron is what caused my aunt's breast cancer? Its a truly evil drug but if it causes cancer than maybe they will finally ban it. Give us poisoned a diagnosis. But make sure no more have to suffer


    littleone on Feb, 25, 2015:

    i was on the lupron shot for my fibroids to keep them from growing so i could have children. i was also Diagnosed with Endometriosis at 28 with fibroids. two months after taking the shot for 6 months, i was Diagnosed with stage 3 breast cancer. it went into my lymohonds then after my chemo and hysterectomy then the cancer was a triple negative. could the lupron shot cause my breast cancer? i do not have the brac 1 or 2 gene. i start my period when i was 11.


    well365 on Dec, 10, 2012:

    I took revlimid for myeloma for 6 months, at 6 months my mammogram showed one mass, the sonogram showed a second. Both are now removed and I am about to have radiation treatment. Revlimid does have a risk of secondary cancers. I would really appreciate knowing if anyone else experienced something similar with revlimid.

    Thank you


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