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Review: could Benadryl cause Atrial fibrillation?

Summary: Atrial fibrillation could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Aspirin, and have Pain.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 396 have Atrial fibrillation. Find out below who they are, when they have Atrial fibrillation and more.

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On Apr, 12, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 403 people (1.54%) have Atrial Fibrillation. They amount to 0.11% of all the 382,712 people who have Atrial Fibrillation on eHealthMe.

Trend of Atrial fibrillation in Benadryl reports

Time on Benadryl when people have Atrial fibrillation * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Atrial fibrillation76.47%20.59%2.94%0.00%0.00%0.00%0.00%

Gender of people who have Atrial fibrillation when taking Benadryl * :

FemaleMale
Atrial fibrillation55.86%44.14%

Age of people who have Atrial fibrillation when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Atrial fibrillation0.00%0.00%0.27%5.33%1.07%8.80%14.67%69.87%

Severity of Atrial fibrillation when taking Benadryl ** :

leastmoderateseveremost severe
Atrial fibrillation0.00%100.00%0.00%0.00%

How people recovered from Atrial fibrillation ** :

while on the drugafter off the drugnot yet
Atrial fibrillation100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Pain (36 people, 8.93%)
  2. Insomnia (33 people, 8.19%)
  3. Nausea (28 people, 6.95%)
  4. Constipation (21 people, 5.21%)
  5. Depression (21 people, 5.21%)

Top co-used drugs for these people * :

  1. Aspirin (140 people, 34.74%)
  2. Lasix (126 people, 31.27%)
  3. Coumadin (97 people, 24.07%)
  4. Ativan (89 people, 22.08%)
  5. Digoxin (88 people, 21.84%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Atrial fibrillation

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergen. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

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Comments from related studies:

  • From this study (1 year ago):

  • Richard Augello on Apr, 22, 2012:

    Could Benadryl Allergy Liquigels cause A-FIB? I have a history of A-Fib and am on meds for it. My allergies are in full force so I started taking benadryl for the past few days, 1 or 2 liqui gels a day and this morning I went into A-fib.

    Reply

    Lady from NJ on Jan, 24, 2013:

    I am a 57 year old lady from NJ. Never had any issues with my heart EVER till I took two Benedryl the other night and woke up in the morning with Atrial Fibrullation - heart beating 610 beats per minute, had to check into emergency room and the problems that ensued were horrible.
    This stuff is DANGEROUS and it definitely CAUSED the ATRIAL FIBRULLATION however you spell it.
    Good luck

    Reply

  • From this study (2 years ago):

  • Amy on Dec, 20, 2011:

    Took Benadryl with my Multaq last night, had heart issues a-fib type arythmias.... Different from any other heart arythmia ever experienced before... corrected with Metaplol.

    Reply

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