Review: could Benadryl cause Coma?


Coma is found among people who take Benadryl, especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Decadron, and have Pain . We study 28,793 people who have side effects while taking Benadryl from FDA and social media. Among them, 201 have Coma. Find out below who they are, when they have Coma and more.

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Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 32,636 users)


Coma (state of unconsciousness lasting more than six hours) has been reported by people with irritability, weight decreased, suicidal ideation, pain, renal failure acute (latest reports from 25,289 Coma patients).

On Aug, 23, 2016

28,793 people reported to have side effects when taking Benadryl.
Among them, 201 people (0.7%) have Coma

Number of reports submitted per year:

Could Benadryl cause Coma?

Time on Benadryl when people have Coma *:

  • < 1 month: 82.14 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 7.14 %
  • 2 - 5 years: 7.14 %
  • 5 - 10 years: 3.57 %
  • 10+ years: 0.0 %

Gender of people who have Coma when taking Benadryl *:

  • female: 46 %
  • male: 54 %

Age of people who have Coma when taking Benadryl *:

  • 0-1: 1.13 %
  • 2-9: 1.69 %
  • 10-19: 0.0 %
  • 20-29: 5.08 %
  • 30-39: 5.65 %
  • 40-49: 26.55 %
  • 50-59: 23.16 %
  • 60+: 36.72 %

Top conditions involved for these people *:

  • Pain (23 people)
  • Depression (18 people)
  • Insomnia (14 people)
  • Back Pain (13 people)
  • Nausea (11 people)

Top co-used drugs for these people *:

  • Decadron (38 people)
  • Tylenol (34 people)
  • Neurontin (23 people)
  • Klonopin (22 people)
  • Ativan (22 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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