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Review: could Benadryl cause Depression?

Summary: Depression is found among people who take Benadryl, especially for people who are female, 40-49 old, have been taking the drug for < 1 month, also take medication Zometa, and have Pain.

We study 26,435 people who have side effects while taking Benadryl from FDA and social media. Among them, 974 have Depression. Find out below who they are, when they have Depression and more.

You are not alone: join a mobile support group for people who take Benadryl and have Depression >>>

 

 

 

 

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

Depression

Depression has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, acne. (latest reports from 277,322 Depression patients)

On Feb, 13, 2015: 26,425 people reported to have side effects when taking Benadryl. Among them, 1,084 people (4.10%) have Depression.

Trend of Depression in Benadryl reports

Time on Benadryl when people have Depression * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Depression72.73%3.64%0.00%1.82%9.09%5.45%7.27%

Gender of people who have Depression when taking Benadryl * :

FemaleMale
Depression65.47%34.53%

Age of people who have Depression when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Depression0.00%0.33%4.14%8.40%12.76%29.55%23.99%20.83%

Severity of Depression when taking Benadryl ** :

leastmoderateseveremost severe
Depression0.00%50.00%41.67%8.33%

How people recovered from Depression ** :

while on the drugafter off the drugnot yet
Depression0.00%12.50%87.50%

Top conditions involved for these people * :

  1. Pain (148 people, 13.65%)
  2. Depression (92 people, 8.49%)
  3. Hypertension (78 people, 7.20%)
  4. Smoking cessation therapy (48 people, 4.43%)
  5. Multiple myeloma (47 people, 4.34%)

Top co-used drugs for these people * :

  1. Zometa (233 people, 21.49%)
  2. Prilosec (203 people, 18.73%)
  3. Aspirin (187 people, 17.25%)
  4. Ativan (187 people, 17.25%)
  5. Ambien (183 people, 16.88%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of benadryl and depression on

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  • Are you mental on methadone
    My doctor changed my pain medication back in May of 2014 . I was pleased with how well it handle my back pain and was pleased with how inexpensive it was. My husband had been using the same drug with great results. It wasn't until about a month later I started to notice just feelings of sadness. I didn't think too much of it but then I would get such strong feelings of despair really bad that I would just cry. I also started getting a lot of panic attacks I had so much anxiety at times it prevented me from doing things. At one point I really thought I was having some sort of break down, but the feelings would have highs and lows and sometimes I would have a day with out them. Eventually after being on them for 7 months I went to my doctor and asked if it were possible I was experiencing these feelings from the Methadone. He wasn't sure but with it all happening right after I started taking them he decided to put me on something else. It's been about three weeks and even though the feelings are still there they are not as strong and seem to be passing. I hope as time goes I will feel like myself again and hope never to have to experience something like that again.
  • Low potasium and mood
    While being treated for cancer about 3 years ago and thus taking a number of blood tests, I was diagnosed with low potassium level and prescribed a regular dosage. I had noticed that when I forgot to take my potassium pills, I soon began to feel more depressed than usual and to feel anxious. Taking the ills soon alleviated these symptoms. (I have had depression for most of my life but long ago decided against taking any of the anti-depression Rx pills because I disliked their side effects, especially on my ability to think clearly.) Very recently I finally got around to looking on the Internet to see whether low potassium was associated with mood disorders _ and I found that it was. This site apparently didn't study anyone my age (I'm 78), so I decided to offer these comments. I have at least one grandchild who has been formally diagnosed with depression, and one who is ADHD. Before finding that the relationship of mood and low potassium was formally known, I had suggested to their parent in a low-key way that perhaps she and they should check with their doctors about their potassium levels. Now I'm quite sure that is something they and their doctors should consider. Meanwhile, I am glad to have found formal study of what had been to me only an anecdotal kind of belief that the two were linked. More importantly, in all my years of doctor visits, no doctor and no psychologist has ever mentioned this link to me. Therefore, I hope that somehow this link is brought more to the forefront of medical attention.
  • Suboxone treatment may have caused my trichotillomania
    It's a long story of how I became addicted to opiates after 15+ years of chronic pain, but I decided to give up pain killers and try suboxone/subutex treatment. Shortly thereafter, I began pulling hair. First from my head, then when the bald spots became too obvious I started pulling from all over. It seemed to be triggered by stress or anxiety but not always. I did not make an association until recently, when I finally stopped the suboxone. It was two weeks of miserable withdrawal, much worse than from pain killers themselves, but I am finally out of the haze I'd be in all of that time, and I have no urge to pull hair whatsoever. I don't know how often the association of suboxone use and trichotillomania has been examined, but I wanted to share my experience in case anyone else is in a similar situation. Also, if you are considering starting suboxone treatment, don't. Withdrawal from opiates will lead to a few pretty rough days, but that's nothing compared to what you'll go through during suboxone withdrawal.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Melixacam and depression
    For herniated disc I was prescribed meloxicam . I experienced nausea, dizziness, and overwhelming depression. By the evening it had worn off and it did nothing for my pain and perhaps even increased my aching pain. Several months later I tried it again and had the same reaction. I was not taking any other medication with it. I do not suffer from depression and I am an active upbeat person.

More reviews for: Benadryl, Depression

Comments from related studies:

  • From this study (9 months ago):

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    Reply

  • From this study (1 year ago):

  • Left side facial nerve pain due to enlarged cheekbone pressing on 5 th cranial nerve. Believed to have also trigeminal neuralgia type 2 due to procedures in attempts to alleviate cranial nerve pain.
    Diagnosed with pseudoporphyria 2 months ago. Believed to be brought on by nsaid medications. Auto immune diseases not tested for or ruled out.
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    Reply

  • From this study (2 years ago):

  • I am a 44 year old female with a very low testerone level of 3. I recently just got off of the birth control pill and have suffered from depression and anxiety for half of my life. I have recently reduced the Baclofen and Paxil and have started to feel worse. Can you please let me know the interactions, symptoms and side effects of all these pills?

    Reply

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