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Review: could Benadryl cause Edema?

Summary: Edema could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Zometa, and have Breast cancer.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 421 have Edema. Find out below who they are, when they have Edema and more.

On Apr, 7, 2014: 26,189 people reported to have side effects when taking Benadryl. Among them, 388 people (1.48%) have Edema. They amount to 0.22% of all the 178,770 people who have Edema on eHealthMe.

Trend of Edema in Benadryl reports

Time on Benadryl when people have Edema * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Edema95.24%0.00%0.00%0.00%0.00%0.00%4.76%

Gender of people who have Edema when taking Benadryl * :

FemaleMale
Edema79.39%20.61%

Age of people who have Edema when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Edema0.00%2.05%2.63%4.97%5.56%21.93%30.41%32.46%

Severity of Edema when taking Benadryl ** :

leastmoderateseveremost severe
Edema0.00%66.67%0.00%33.33%

How people recovered from Edema ** :

n/a

Top conditions involved for these people * :

  1. Breast cancer (70 people, 18.04%)
  2. Metastases to bone (56 people, 14.43%)
  3. Depression (50 people, 12.89%)
  4. Pain (46 people, 11.86%)
  5. Breast cancer metastatic (38 people, 9.79%)

Top co-used drugs for these people * :

  1. Zometa (172 people, 44.33%)
  2. Aredia (138 people, 35.57%)
  3. Celebrex (94 people, 24.23%)
  4. Ambien (93 people, 23.97%)
  5. Decadron (93 people, 23.97%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Edema

You can also:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 years ago):

  • It's not lowering my bp that much. I feel lousy and have noticed occasional urinary incontinence which I NEVER have had before taking atenolol.

    Reply

  • From this study (4 years ago):

  • Having swelling of different body parts. fingers, toes, butt cheek, lip, tongue, face, throat, hands, feet. 3 to 4 inch welts show once in awhile

    Reply

  • From this study (5 years ago):

  • took Midol pink and had rash the next day. Took benadryl for rash. Hives are worse and some swelling of mouth and face

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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