Review: could Benadryl cause Edema?


Edema is found among people who take Benadryl, especially for people who are female, 50-59 old , have been taking the drug for < 1 month, also take medication Aredia, and have Breast cancer . We study 28,793 people who have side effects while taking Benadryl from FDA and social media. Among them, 314 have Edema. Find out below who they are, when they have Edema and more.

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Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)


Edema (excess of watery fluid collecting in the cavities or tissues of the body) has been reported by people with high blood pressure, breathing difficulty, pain, joint pain, fatigue (latest reports from 27,367 Edema patients).

On Aug, 25, 2016

28,793 people reported to have side effects when taking Benadryl.
Among them, 314 people (1.09%) have Edema

Number of reports submitted per year:

Could Benadryl cause Edema?

Time on Benadryl when people have Edema *:

  • < 1 month: 83.33 %
  • 1 - 6 months: 8.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 4.17 %
  • 10+ years: 4.17 %

Gender of people who have Edema when taking Benadryl *:

  • female: 77.23 %
  • male: 22.77 %

Age of people who have Edema when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 2.36 %
  • 10-19: 3.94 %
  • 20-29: 5.51 %
  • 30-39: 7.09 %
  • 40-49: 20.47 %
  • 50-59: 33.46 %
  • 60+: 27.17 %

Severity if Edema when taking Benadryl **:

  • least: 0.0 %
  • moderate: 66.67 %
  • severe: 0.0 %
  • most severe: 33.33 %

How people recovered from Edema **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Breast Cancer (73 people)
  • Pain (48 people)
  • Depression (46 people)
  • Hot Flush (35 people)
  • Metastases To Bone (32 people)

Top co-used drugs for these people *:

  • Aredia (87 people)
  • Zometa (83 people)
  • Taxol (64 people)
  • Celebrex (62 people)
  • Compazine (56 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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