Review: could Benadryl cause Euphoric Mood?


Euphoric mood is found among people who take Benadryl, especially for people who are female, 30-39 old also take medication Ambien, and have Pain . We study 37,611 people who have side effects while taking Benadryl from FDA and social media. Among them, 44 have Euphoric mood. Find out below who they are, when they have Euphoric mood and more.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 44,651 users)

Euphoric Mood

Euphoric mood (excessively happy but may become angry or irritable) has been reported by people with pain, depression, stress and anxiety, quit smoking, fibromyalgia (latest reports from 6,760 Euphoric mood patients).

On Sep, 15, 2016

37,611 people reported to have side effects when taking Benadryl.
Among them, 44 people (0.12%) have Euphoric Mood

Number of reports submitted per year:

Could Benadryl cause Euphoric mood?

Gender of people who have Euphoric Mood when taking Benadryl *:

  • female: 65 %
  • male: 35 %

Age of people who have Euphoric Mood when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 3.33 %
  • 10-19: 6.67 %
  • 20-29: 6.67 %
  • 30-39: 36.67 %
  • 40-49: 20.0 %
  • 50-59: 10.0 %
  • 60+: 16.67 %

Top conditions involved for these people *:

  • Pain (6 people, 13.64%)
  • Hypertension (4 people, 9.09%)
  • Crohn's Disease (4 people, 9.09%)
  • Fibromyalgia (2 people, 4.55%)
  • Back Pain (2 people, 4.55%)

Top co-used drugs for these people *:

  • Suboxone (7 people, 15.91%)
  • Ambien (7 people, 15.91%)
  • Zantac (4 people, 9.09%)
  • Wellbutrin (4 people, 9.09%)
  • Tylenol (4 people, 9.09%)

Top other side effects for these people *:

  • Fatigue (11 people, 25.00%)
  • Weight Increased (10 people, 22.73%)
  • Depression (10 people, 22.73%)
  • Insomnia (9 people, 20.45%)
  • Loss Of Consciousness (8 people, 18.18%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Euphoric mood when taking Benadryl?

Browse all side effects of Benadryl

a b c d e f g h i j k l m n o p q r s t u v w x y z

Drugs that are associated with Euphoric mood

Euphoric mood

Could your condition cause Euphoric mood

Euphoric mood

Related studies

Can you answer these questions?

More questions for: Benadryl, Euphoric mood

You may be interested in these reviews

More reviews for: Benadryl, Euphoric mood

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.