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Review: could Benadryl cause Low blood pressure (Hypotension)?

Summary: Low blood pressure is found among people who take Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Decadron, and have Pain.

We study 26,414 people who have side effects while taking Benadryl from FDA and social media. Among them, 1,458 have Low blood pressure. Find out below who they are, when they have Low blood pressure and more.

You are not alone: join a mobile support group for people who take Benadryl and have Low blood pressure >>>

 

 

 

 

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,380 Benadryl users)

Low blood pressure

Low blood pressure (abnormally low blood pressure) has been reported by people with high blood pressure, pain, multiple sclerosis, osteoporosis, depression. (latest reports from 107,406 Low blood pressure patients)

On Jan, 7, 2015: 26,414 people reported to have side effects when taking Benadryl. Among them, 1,458 people (5.52%) have Low Blood Pressure.

Trend of Low blood pressure in Benadryl reports

Time on Benadryl when people have Low blood pressure * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Low blood pressure88.30%11.11%0.00%0.00%0.00%0.00%0.58%

Gender of people who have Low blood pressure when taking Benadryl * :

FemaleMale
Low blood pressure56.17%43.83%

Age of people who have Low blood pressure when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Low blood pressure0.57%2.00%4.86%3.21%6.00%12.79%20.71%49.86%

Severity of Low blood pressure when taking Benadryl ** :

leastmoderateseveremost severe
Low blood pressure28.57%14.29%42.86%14.29%

How people recovered from Low blood pressure ** :

while on the drugafter off the drugnot yet
Low blood pressure33.33%0.00%66.67%

Top conditions involved for these people * :

  1. Pain (76 people, 5.21%)
  2. Hypertension (72 people, 4.94%)
  3. Depression (57 people, 3.91%)
  4. Nausea (56 people, 3.84%)
  5. Non-small cell lung cancer (47 people, 3.22%)

Top co-used drugs for these people * :

  1. Decadron (340 people, 23.32%)
  2. Zofran (266 people, 18.24%)
  3. Tylenol (232 people, 15.91%)
  4. Ativan (225 people, 15.43%)
  5. Aspirin (212 people, 14.54%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You may be interested at these reviews (Write a review):

  • Nardil side effects and my experience taking it
    I have been on many SSRI AND SNRI medications that quickly became ineffective. Was told by a doctor friend that she had been on an MAOI inhibitor for many years with good results. After going thru a horrible withdrawal detox from the SNRI I had been on and then a period of no med at all I was started on Nardil, as I needed assistance from Pfizer, the many turner in affording the medicine. My friend was on Parnate, a different brand of an MAOI.
    Within days, not weeks I felt the depression lifting. It was the most dramatic and fastest response I had ever had to any antidepressant .
    Then the fainting started, falls with resulting broken ribs, bedridden and alone I lost over25 lbs in two weeks. I was of normal weight for my height. After I was able to function again, I noticed that my legs were very weak. We cut my dosage from 3 pills daily to 2. That seemed to have stopped the faint spells. However I still had/have low blood pressure that I monitor at home. My Systolic BP was usually in the 70's and 80's. One of the lowest was shocking to me. It was 52/27.
    My son is a hospital RN and said they would never discharge a patient with Bp that low.
    He was very worried about me as I live alone. I fainted twice after climbing the 13 stairs to my bedroom. The first fall was very bad as I was unconscious and my ribs were severely injured/fractured completely around the front and back and was in terrific pain. I took to my bed and did not seek medical attn. my last ambulance ride to the hospital a mile from my house cost $1000 and since I have no income or relatives/friends to call for help, I just lay in bed I awful pain that was woes when I tried to get out of bed. Thus I lost 25 lbs of muscle, since I had very little body fat.
    It has been two months since that fall and still have one area of pain in the front left ribs and a swollen spleen. The doctor gave me no additional meds and just said to give my body more time to heal. So once again was changed to 2 pills daily instead of 3. The hypotension and fainting got better. But I am now left with very weak legs and fall easily and frequently. Guess I lost a lot of muscle mass with the weight loss. However after a lifetime of depression, Nardil works wonderfully for that which had been long-standing and severe for so many years. People noticed the change in me shortly after starting the Nardil. But I am stubborn about going off it despite all the side effects because it works so much better than any of the many others I had been put on over the years.
    I am soon going to start doing leg exercises with ankle weights, starting with light weights are first and gradually increasing the weight as I hopefully rebuild my muscles and strength.
    Also my vision has gotten blurry and I feel slightly retarded after the weeks in bed when I was breathing very shallowly due to the broken ribs and my brain was deprived of adequate oxygen.
    Prior to all this I had an IQ of 140. If they tested me now, I know I would be way down from that. Also doing lung/breathing exercises to expand my lungs so I can take in more air with each breath.
    So that is my story of Nardil, hypotension, and depression. I had to really suffer to remain on this med that worked so magically for me after so many failures. It meant that much to me to not be crippled by depression.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.

More reviews for: Benadryl, Low blood pressure

Comments from related studies:

  • From this study (3 months ago):

  • on peritoneal dialysis

    Reply

  • From this study (5 months ago):

  • BP ranges 125-130 over 75-87 when getting up prior to meds to 90-50 sometimes in the evening. I am a little stressed and so diphenhydramine helps me sleep along with melatonin. THese are OTC

    Reply

  • From this study (2 years ago):

  • All adverse effects are tolerable and preferential to extreme pain and fatigue which can cause severe MS exacerbation.

    Reply

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