Review: could Benadryl cause Nosebleed?


Nosebleed is found among people who take Benadryl, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Zofran, and have Osteoporosis . We study 28,793 people who have side effects while taking Benadryl from FDA and social media. Among them, 232 have Nosebleed. Find out below who they are, when they have Nosebleed and more.

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Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)


Nosebleed (bleeding from nose) has been reported by people with alanine aminotransferase increased, pain, agitation, febrile neutropenia, insomnia (latest reports from 28,763 Nosebleed patients).

On Aug, 26, 2016

28,793 people reported to have side effects when taking Benadryl.
Among them, 232 people (0.81%) have Nosebleed

Number of reports submitted per year:

Could Benadryl cause Nosebleed?

Time on Benadryl when people have Nosebleed *:

  • < 1 month: 62.5 %
  • 1 - 6 months: 18.75 %
  • 6 - 12 months: 6.25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 6.25 %
  • 5 - 10 years: 6.25 %
  • 10+ years: 0.0 %

Gender of people who have Nosebleed when taking Benadryl *:

  • female: 66.96 %
  • male: 33.04 %

Age of people who have Nosebleed when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 1.13 %
  • 10-19: 2.26 %
  • 20-29: 3.39 %
  • 30-39: 3.95 %
  • 40-49: 18.64 %
  • 50-59: 18.08 %
  • 60+: 52.54 %

Severity if Nosebleed when taking Benadryl **:

  • least: 0.0 %
  • moderate: 0.0 %
  • severe: 100 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Osteoporosis (19 people)
  • Breast Cancer (15 people)
  • Pain (11 people)
  • Gastrooesophageal Reflux Disease (9 people)
  • Idiopathic Thrombocytopenic Purpura (8 people)

Top co-used drugs for these people *:

  • Zofran (52 people)
  • Tylenol (49 people)
  • Decadron (36 people)
  • Zometa (35 people)
  • Prevacid (34 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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