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Review: could Benadryl cause Panic attack?

We study 26,361 people who have side effects while taking Benadryl from FDA and social media. Among them, 135 have Panic attack. Find out below who they are, when they have Panic attack and more.

Stay connected: join a mobile support group for people who take Benadryl and have Panic attack >>>

Benadryl

Benadryl (latest outcomes from 29,317 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Panic attack

Panic attack (latest reports from 121,059 patients) has been reported by people with depression, stress and anxiety, quit smoking, panic disorder, pain.

On Jul, 11, 2014: 26,359 people reported to have side effects when taking Benadryl. Among them, 135 people (0.51%) have Panic Attack. They amount to 0.11% of all the 121,069 people who have Panic Attack on eHealthMe.

Trend of Panic attack in Benadryl reports

Time on Benadryl when people have Panic attack * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Panic attack33.33%22.22%0.00%11.11%11.11%11.11%11.11%

Gender of people who have Panic attack when taking Benadryl * :

FemaleMale
Panic attack74.47%25.53%

Age of people who have Panic attack when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Panic attack0.00%0.00%3.36%15.97%12.61%47.06%15.13%5.88%

Severity of Panic attack when taking Benadryl ** :

leastmoderateseveremost severe
Panic attack0.00%33.33%33.33%33.33%

How people recovered from Panic attack ** :

while on the drugafter off the drugnot yet
Panic attack0.00%50.00%50.00%

Top conditions involved for these people * :

  1. Pain (17 people, 12.59%)
  2. Depression (12 people, 8.89%)
  3. Panic attack (9 people, 6.67%)
  4. Bipolar disorder (8 people, 5.93%)
  5. Smoking cessation therapy (7 people, 5.19%)

Top co-used drugs for these people * :

  1. Klonopin (24 people, 17.78%)
  2. Prozac (24 people, 17.78%)
  3. Percocet (23 people, 17.04%)
  4. Xanax (22 people, 16.30%)
  5. Vicodin (22 people, 16.30%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Dave (1 year ago):

Just a quick comment on Benadryl-caused panic attacks. Last Xmas was extremely stressful. I ran out of my Xanax, and could not get a refill. I know that Gravol anti-nauseant has the same drug in it as Benadryl, so I bought a pack of Benadryl to ease my anxiety. I took 2, 50 mg. Benadryl's, and within 20 minutes I was experiencing the WORST panic attack I have ever had. I was hearing and seeing things, couldn't breath, kept getting mini-seizures. I took LSD once as a 17 year old and had a 48 hour long, extremely bad "trip" on the LSD. The Benadryl was at least 10x worse than the LSD.

50 year old male
152 lbs
5'7"
perfect physical health

I am just wondering why Gravol has a "good" effect on me, but Benadryl, with the same active ingredient causes the severe panic attacks. I am wondering if the makers of Benadryl add amphetamine salt to the Benadryl as I hear amphetamines are useful for breathing problems due to allergies..am I correct?
Reply the comment

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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Could it be a symptom from a condition:

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