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Review: could Benadryl cause Raynaud's phenomenon?





Summary: Raynaud's phenomenon is found among people who take Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Prevacid, and have Osteoporosis.

We study 26,402 people who have side effects while taking Benadryl from FDA and social media. Among them, 29 have Raynaud's phenomenon. Find out below who they are, when they have Raynaud's phenomenon and more.

You are not alone: join a mobile support group for people who take Benadryl and have Raynaud's phenomenon >>>

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 29,367 users)

Raynaud's phenomenon

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) has been reported by people with osteoporosis, high blood pressure, rheumatoid arthritis, multiple sclerosis, attention deficit hyperactivity disorder.(latest reports from Raynaud's phenomenon 2,818 patients)

On Nov, 28, 2014: 26,402 people reported to have side effects when taking Benadryl. Among them, 29 people (0.11%) have Raynaud's Phenomenon.

Trend of Raynaud's phenomenon in Benadryl reports

Time on Benadryl when people have Raynaud's phenomenon * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Raynaud's phenomenon100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Raynaud's phenomenon when taking Benadryl * :

FemaleMale
Raynaud's phenomenon93.10%6.90%

Age of people who have Raynaud's phenomenon when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Raynaud's phenomenon0.00%0.00%0.00%33.33%16.67%0.00%16.67%33.33%

Severity of Raynaud's phenomenon when taking Benadryl ** :

n/a

How people recovered from Raynaud's phenomenon ** :

n/a

Top conditions involved for these people * :

  1. Osteoporosis (15 people, 51.72%)
  2. Rheumatoid arthritis (4 people, 13.79%)
  3. Premenstrual syndrome (2 people, 6.90%)
  4. Acne (2 people, 6.90%)
  5. Pain (2 people, 6.90%)

Top co-used drugs for these people * :

  1. Prevacid (18 people, 62.07%)
  2. Demerol (16 people, 55.17%)
  3. Zantac (16 people, 55.17%)
  4. Diazepam (15 people, 51.72%)
  5. Amoxicillin (15 people, 51.72%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Raynaud's Phenomenon while taking Benadryl?

You are not alone! Join a mobile support group:
- support group for people who take Benadryl and have Raynaud's Phenomenon
- support group for people who take Benadryl
- support group for people who have Raynaud's Phenomenon

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You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    (Posted by a 63 year old woman who has Headaches, and takes Diphenhydramine Hydrochloride)
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    (Posted by a 54 year old man who has Nightmare, Hard Time Sleeping, and takes Benadryl)
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    (Posted by a 50 year old woman who has Completed Suicide, and takes Alcohol, Methenamine Hippurate, Xanax, Benadryl)
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    (Posted by a 62 year old woman who has Narcolepsy, Prinzmetal's Angina , Antiphospholipid Syndrome, High Blood Pressure, Obsessive-compulsive Personality Disorder, Cyclic Vomiting Syndrome, Migraine With Aura, Herniated Intervertebral Disk, Osteoarthritis, Fibromyalgia, Rheumatoid Arthritis, Diabetes Mellitus Insulin-dependent, Bipolar I Disorder, and takes Benadryl, Baclofen, Plaquenil, Nitro-bid, Maxalt-mlt, Imitrex, Zofran Odt, Ms Contin, Clonidine, Amlodipine Besylate, Novolog Flexpen, Levemir Flexpen, Halcion, Valium, Primidone, Neurontin, Trileptal)
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Leg pain and occasional arm and hand pain
    (Posted by a 69 year old woman who has Lower Leg Pain, and takes Benadryl)
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night.

    I finally realized after suffering this over and over for months, that it only happened when I had taken benadryl.

    It seems that the benadryl causes it after taking it within one hour, I don't know why I didn't connect this until yesterday. Sometimes, more rarely, I also had arm and hand pain.

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