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Review: could Benadryl cause Raynaud's phenomenon?

Summary: Raynaud's phenomenon could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Prevacid, and have Osteoporosis.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 29 have Raynaud's phenomenon. Find out below who they are, when they have Raynaud's phenomenon and more.

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Benadryl

Benadryl (latest outcomes from 29,278 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Raynaud's phenomenon

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) (latest reports from 12,259 patients) has been reported by people with osteoporosis, high blood pressure, rheumatoid arthritis, multiple sclerosis, attention deficit hyperactivity disorder.

On Apr, 10, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 29 people (0.11%) have Raynaud's Phenomenon. They amount to 0.24% of all the 12,243 people who have Raynaud's Phenomenon on eHealthMe.

Trend of Raynaud's phenomenon in Benadryl reports

Time on Benadryl when people have Raynaud's phenomenon * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Raynaud's phenomenon100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Raynaud's phenomenon when taking Benadryl * :

FemaleMale
Raynaud's phenomenon93.10%6.90%

Age of people who have Raynaud's phenomenon when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Raynaud's phenomenon0.00%0.00%0.00%33.33%16.67%0.00%16.67%33.33%

Severity of Raynaud's phenomenon when taking Benadryl ** :

n/a

How people recovered from Raynaud's phenomenon ** :

n/a

Top conditions involved for these people * :

  1. Osteoporosis (15 people, 51.72%)
  2. Blood pressure (4 people, 13.79%)
  3. Rheumatoid arthritis (4 people, 13.79%)
  4. Premenstrual syndrome (2 people, 6.90%)
  5. Acne (2 people, 6.90%)

Top co-used drugs for these people * :

  1. Prevacid (18 people, 62.07%)
  2. Zantac (16 people, 55.17%)
  3. Demerol (16 people, 55.17%)
  4. Sonata (15 people, 51.72%)
  5. Adapalene (15 people, 51.72%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Raynaud's phenomenon

You can also:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 days ago):

  • Been I'll for 9 months. Just recently found pneumonia. Can't afford dermatologist and do for doesn't know what the hives are. You can write with your finger on my skin and it will show up.

    Reply

  • From this study (6 days ago):

  • I never had any symptoms of raynauds until is was put on methotrexate,and then Enbrel,and now Humira.I used a automotive laser thermometer to check my arm
    temp. which was 97 degrees,however my fingers on the same arm were between
    69-72 degrees.

    Reply

  • From this study (1 week ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.

    Reply

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