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Review: could Benadryl cause Rebound effect?

Summary: Rebound effect could be caused by Benadryl, especially for people who are female, 60+ old, also take Digoxin, and have Nasal congestion.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 5 have Rebound effect. Find out below who they are, when they have Rebound effect and more.

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Benadryl

Benadryl (latest outcomes from 29,278 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergen.

Rebound effect

Rebound effect (take-back effect) (latest reports from 2,319 patients) has been reported by people with multiple sclerosis, insomnia, migraine, depression, headache.

On Apr, 10, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 5 people (0.02%) have Rebound Effect. They amount to 0.22% of all the 2,316 people who have Rebound Effect on eHealthMe.

Trend of Rebound effect in Benadryl reports

Time on Benadryl when people have Rebound effect * :

n/a

Gender of people who have Rebound effect when taking Benadryl * :

FemaleMale
Rebound effect100.00%0.00%

Age of people who have Rebound effect when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Rebound effect0.00%0.00%0.00%0.00%0.00%50.00%0.00%50.00%

Severity of Rebound effect when taking Benadryl ** :

n/a

How people recovered from Rebound effect ** :

n/a

Top conditions involved for these people * :

  1. Nasal congestion (1 people, 20.00%)
  2. Muscle spasticity (1 people, 20.00%)

Top co-used drugs for these people * :

  1. Digoxin (1 people, 20.00%)
  2. Potassium chloride (1 people, 20.00%)
  3. Flagyl (1 people, 20.00%)
  4. Demadex (1 people, 20.00%)
  5. Macrodantin (1 people, 20.00%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Rebound effect

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergen. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

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  • From this study (1 week ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.

    Reply

  • From this study (1 week ago):

  • Is there any interaction or problems taking these three medication at the same time?

    Reply

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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