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Review: could Benadryl cause Restless legs?

Summary: Restless legs could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Coumadin, and have Gastrooesophageal reflux disease.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 80 have Restless legs. Find out below who they are, when they have Restless legs and more.

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Benadryl

Benadryl (latest outcomes from 29,278 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Restless legs

Restless legs (a powerful urge to move your legs) (latest reports from 67,446 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Apr, 11, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 80 people (0.31%) have Restless Legs. They amount to 0.12% of all the 67,325 people who have Restless Legs on eHealthMe.

Trend of Restless legs in Benadryl reports

Time on Benadryl when people have Restless legs * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs70.00%0.00%0.00%10.00%10.00%0.00%10.00%

Gender of people who have Restless legs when taking Benadryl * :

FemaleMale
Restless legs70.13%29.87%

Age of people who have Restless legs when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs0.00%0.00%0.00%4.62%1.54%23.08%18.46%52.31%

Severity of Restless legs when taking Benadryl ** :

leastmoderateseveremost severe
Restless legs0.00%0.00%66.67%33.33%

How people recovered from Restless legs ** :

n/a

Top conditions involved for these people * :

  1. Gastrooesophageal reflux disease (11 people, 13.75%)
  2. Crohn's disease (8 people, 10.00%)
  3. Restless legs syndrome (5 people, 6.25%)
  4. Diabetes mellitus (5 people, 6.25%)
  5. Hypothyroidism (4 people, 5.00%)

Top co-used drugs for these people * :

  1. Coumadin (28 people, 35.00%)
  2. Pepcid (25 people, 31.25%)
  3. Zofran (24 people, 30.00%)
  4. Prilosec (24 people, 30.00%)
  5. Levaquin (22 people, 27.50%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Restless legs

You can also:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (1 year ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

  • From this study (1 year ago):

  • Johanna on Dec, 18, 2012:

    I am a59 year old woman and I used benylin to help me though my cold symptoms , but instead of getting a good night sleep I ended up with the most severe restless leg syndrom.Years ago when I experienced menopausal insomnia I tried sleep aid and the same thing happened . I figured out that it is the ingredient Diphenhydramine Hydrochlorine . there shoul be a warning on the label . Can someone use this information to help people that experience rest less les syndrom.

    Reply

Can you answer these questions (what is this?):

More questions for: Benadryl, Restless legs

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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