Review: could Benadryl cause Restless legs (Restless Leg Syndrome)?
Summary: Restless legs is found among people who take Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Coumadin, and have Gastrooesophageal reflux disease.
We study 26,414 people who have side effects while taking Benadryl from FDA and social media. Among them, 80 have Restless legs. Find out below who they are, when they have Restless legs and more.
You are not alone: join a mobile support group for people who take Benadryl and have Restless legs >>>
Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,380 Benadryl users)
Restless legs (a powerful urge to move your legs) has been reported by people with osteoporosis, depression, pain, high blood pressure, stress and anxiety. (latest reports from 17,455 Restless legs patients)
On Dec, 28, 2014: 26,414 people reported to have side effects when taking Benadryl. Among them, 80 people (0.30%) have Restless Legs.
Time on Benadryl when people have Restless legs * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Restless legs||70.00%||0.00%||0.00%||10.00%||10.00%||0.00%||10.00% |
Gender of people who have Restless legs when taking Benadryl * :
|Restless legs||70.13%||29.87% |
Age of people who have Restless legs when taking Benadryl * :
|Restless legs||0.00%||0.00%||0.00%||4.62%||1.54%||23.08%||18.46%||52.31% |
Severity of Restless legs when taking Benadryl ** :
|least||moderate||severe||most severe |
|Restless legs||0.00%||0.00%||66.67%||33.33% |
How people recovered from Restless legs ** :
Top conditions involved for these people * :
- Gastrooesophageal reflux disease (11 people, 13.75%)
- Crohn's disease (8 people, 10.00%)
- Restless legs syndrome (5 people, 6.25%)
- Diabetes mellitus (5 people, 6.25%)
- Impaired gastric emptying (4 people, 5.00%)
Top co-used drugs for these people * :
- Coumadin (28 people, 35.00%)
- Pepcid (25 people, 31.25%)
- Prilosec (24 people, 30.00%)
- Zofran (24 people, 30.00%)
- Levaquin (22 people, 27.50%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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- Had nms in 2005, will trileptal increase chance of recurrence?
In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
More reviews for: Benadryl, Restless legs
Comments from related studies:
From this study (2 years ago):
I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.
deerfisherman on Dec, 23, 2012:
Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.
From this study (2 years ago):
Johanna on Dec, 18, 2012:
I am a59 year old woman and I used benylin to help me though my cold symptoms , but instead of getting a good night sleep I ended up with the most severe restless leg syndrom.Years ago when I experienced menopausal insomnia I tried sleep aid and the same thing happened . I figured out that it is the ingredient Diphenhydramine Hydrochlorine . there shoul be a warning on the label . Can someone use this information to help people that experience rest less les syndrom.
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