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Review: could Benadryl cause Restless legs (Restless Leg Syndrome)?

Summary: Restless legs is found among people who take Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Coumadin, and have Gastrooesophageal reflux disease. We study 26,443 people who have side effects while taking Benadryl from FDA and social media. Among them, 81 have Restless legs. Find out below who they are, when they have Restless legs and more.

You are not alone: join a support group for people who take Benadryl and have Restless legs >>>

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>

 

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

Restless legs

Restless legs (a powerful urge to move your legs) has been reported by people with osteoporosis, depression, pain, high blood pressure, stress and anxiety. (latest reports from 17,510 Restless legs patients)

On May, 1, 2015: 26,443 people reported to have side effects when taking Benadryl. Among them, 80 people (0.30%) have Restless Legs.

Trend of Restless legs in Benadryl reports

Time on Benadryl when people have Restless legs * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs70.00%0.00%0.00%10.00%10.00%0.00%10.00%

Gender of people who have Restless legs when taking Benadryl * :

FemaleMale
Restless legs70.13%29.87%

Age of people who have Restless legs when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs0.00%0.00%0.00%4.62%1.54%23.08%18.46%52.31%

Severity of Restless legs when taking Benadryl ** :

leastmoderateseveremost severe
Restless legs0.00%0.00%66.67%33.33%

How people recovered from Restless legs ** :

n/a

Top conditions involved for these people * :

  1. Gastrooesophageal reflux disease (11 people, 13.75%)
  2. Crohn's disease (8 people, 10.00%)
  3. Restless legs syndrome (5 people, 6.25%)
  4. Diabetes mellitus (5 people, 6.25%)
  5. Impaired gastric emptying (4 people, 5.00%)

Top co-used drugs for these people * :

  1. Coumadin (28 people, 35.00%)
  2. Pepcid (25 people, 31.25%)
  3. Prilosec (24 people, 30.00%)
  4. Zofran (24 people, 30.00%)
  5. Levaquin (22 people, 27.50%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Restless Legs while taking Benadryl?

 

You are not alone! Join a support group on :
- support group for people who take Benadryl and have Restless Legs
- support group for people who take Benadryl

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More questions for: Benadryl, Restless legs

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Comments from related studies:

  • From this study (2 weeks ago):

  • I have personality disorder, bipolar,anxiety,insomnia. been off antipsychotics for 9 months

    Reply

  • From this study (2 years ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

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