Benadryl and Serotonin syndrome - from FDA reports


Serotonin syndrome is found among people who take Benadryl, especially for people who are female, 50-59 old also take medication Zofran, and have Depression . We study 40,660 people who have side effects while taking Benadryl from FDA. Among them, 35 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

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Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 44,719 users)

Serotonin Syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 9,744 Serotonin syndrome patients).

On Feb, 02, 2017

40,660 people reported to have side effects when taking Benadryl.
Among them, 35 people (0.09%) have Serotonin Syndrome

Number of reports submitted per year:

Could Benadryl cause Serotonin syndrome?

Gender of people who have Serotonin Syndrome when taking Benadryl *:

  • female: 80 %
  • male: 20 %

Age of people who have Serotonin Syndrome when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 6.67 %
  • 20-29: 0.0 %
  • 30-39: 13.33 %
  • 40-49: 13.33 %
  • 50-59: 43.33 %
  • 60+: 23.33 %

Top conditions involved for these people *:

  • Depression (21 people, 60.00%)
  • Pain (11 people, 31.43%)
  • Stress And Anxiety (9 people, 25.71%)
  • Procedural Pain (7 people, 20.00%)
  • Nausea (7 people, 20.00%)

Top co-used drugs for these people *:

  • Zofran (11 people, 31.43%)
  • Wellbutrin (10 people, 28.57%)
  • Prozac (10 people, 28.57%)
  • Valium (8 people, 22.86%)
  • Promethazine (8 people, 22.86%)

Top other side effects for these people *:

  • Nausea (9 people, 25.71%)
  • Nausea And Vomiting (8 people, 22.86%)
  • Feeling Abnormal (8 people, 22.86%)
  • Fall (8 people, 22.86%)
  • Agitation (8 people, 22.86%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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