Review: could Benadryl cause Serotonin syndrome?
We study 26,361 people who have side effects while taking Benadryl from FDA and social media. Among them, 19 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.
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Benadryl (latest outcomes from 29,317 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,498 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.
On Jul, 13, 2014: 26,359 people reported to have side effects when taking Benadryl. Among them, 19 people (0.07%) have Serotonin Syndrome. They amount to 0.06% of all the 34,494 people who have Serotonin Syndrome on eHealthMe.
Time on Benadryl when people have Serotonin syndrome * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Serotonin syndrome||100.00%||0.00%||0.00%||0.00%||0.00%||0.00%||0.00% |
Gender of people who have Serotonin syndrome when taking Benadryl * :
|Serotonin syndrome||68.42%||31.58% |
Age of people who have Serotonin syndrome when taking Benadryl * :
|Serotonin syndrome||0.00%||0.00%||20.00%||0.00%||13.33%||20.00%||20.00%||26.67% |
Severity of Serotonin syndrome when taking Benadryl ** :
|least||moderate||severe||most severe |
|Serotonin syndrome||0.00%||100.00%||0.00%||0.00% |
How people recovered from Serotonin syndrome ** :
|while on the drug||after off the drug||not yet |
|Serotonin syndrome||0.00%||0.00%||100.00% |
Top conditions involved for these people * :
- Depression (8 people, 42.11%)
- Atrial fibrillation (3 people, 15.79%)
- Insomnia (3 people, 15.79%)
- Ill-defined disorder (3 people, 15.79%)
- Mood swings (2 people, 10.53%)
Top co-used drugs for these people * :
- Zoloft (7 people, 36.84%)
- Seroquel (5 people, 26.32%)
- Geodon (5 people, 26.32%)
- Wellbutrin (4 people, 21.05%)
- Zofran (3 people, 15.79%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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I have been having charlie horses for about a month. I also have muscle twitching that started in one leg and within two weeks it has spread to my entire body. my blood work came back normal.
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27 L knee operations, three massive L knee infections resulting in a third and final arthoplasty revision. Extensive soft tissue damage resulting in perminante subqutanious sutuers and locking full leg brace, also perminante.
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From this study (2 weeks ago):
Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.
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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.
What is Benadryl used for and how effective is it:
Other drugs that are used to treat the same conditions:
Could it be a symptom from a condition:
Drugs in real world that are associated with:
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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
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