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Review: could Benadryl cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Zoloft, and have Depression.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 19 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

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Benadryl

Benadryl (latest outcomes from 29,278 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergen.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,373 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Apr, 10, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 19 people (0.07%) have Serotonin Syndrome. They amount to 0.06% of all the 34,365 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Benadryl reports

Time on Benadryl when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Serotonin syndrome when taking Benadryl * :

FemaleMale
Serotonin syndrome68.42%31.58%

Age of people who have Serotonin syndrome when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%20.00%0.00%13.33%20.00%20.00%26.67%

Severity of Serotonin syndrome when taking Benadryl ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (8 people, 42.11%)
  2. Atrial fibrillation (3 people, 15.79%)
  3. Insomnia (3 people, 15.79%)
  4. Ill-defined disorder (3 people, 15.79%)
  5. Mood swings (2 people, 10.53%)

Top co-used drugs for these people * :

  1. Zoloft (7 people, 36.84%)
  2. Seroquel (5 people, 26.32%)
  3. Geodon (5 people, 26.32%)
  4. Wellbutrin (4 people, 21.05%)
  5. Zofran (3 people, 15.79%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Serotonin syndrome

You can also:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergen. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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  • From this study (1 week ago):

  • Is there any interaction or problems taking these three medication at the same time?

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