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Review: could Benadryl cause Serotonin syndrome?

We study 26,366 people who have side effects while taking Benadryl from FDA and social media. Among them, 19 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

Stay connected: join a mobile support group for people who take Benadryl and have Serotonin syndrome >>>

Benadryl

Benadryl (latest outcomes from 29,322 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergen.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,513 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Aug, 12, 2014: 26,364 people reported to have side effects when taking Benadryl. Among them, 19 people (0.07%) have Serotonin Syndrome. They amount to 0.06% of all the 34,500 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Benadryl reports

Time on Benadryl when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Serotonin syndrome when taking Benadryl * :

FemaleMale
Serotonin syndrome68.42%31.58%

Age of people who have Serotonin syndrome when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%20.00%0.00%13.33%20.00%20.00%26.67%

Severity of Serotonin syndrome when taking Benadryl ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (8 people, 42.11%)
  2. Atrial fibrillation (3 people, 15.79%)
  3. Insomnia (3 people, 15.79%)
  4. Ill-defined disorder (3 people, 15.79%)
  5. Mood swings (2 people, 10.53%)

Top co-used drugs for these people * :

  1. Zoloft (7 people, 36.84%)
  2. Seroquel (5 people, 26.32%)
  3. Geodon (5 people, 26.32%)
  4. Wellbutrin (4 people, 21.05%)
  5. Zofran (3 people, 15.79%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Benadryl and have Serotonin Syndrome
- group for people who take Benadryl
- group for people who have Serotonin Syndrome

Comments from related studies:

  • From this study (2 days ago):

  • I've always had mood swings and have suffered with depression throughout my life. Recently I started taking Benadryl at night to help with allergies. I found that it helped me sleep better also. I'm not sure if I'm just noticing that I may have a mood disorder that's always been there or if it is caused by the Benadryl requip combo

    Reply

  • From this study (2 weeks ago):

  • I am vigorous and healthy. My fainting happens when my head moves backward rapidly such as when I lie down in bed too fast. I recover quickly with no additional effects. I am not sure this is caused by my medication.

    Reply

  • From this study (4 weeks ago):

  • Ringing started after first few doses of Benadryl

    Reply

Post a new comment    OR    Read more comments

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More reviews for: Benadryl, Serotonin syndrome

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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