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Review: could Benadryl cause Serotonin syndrome?

We study 26,361 people who have side effects while taking Benadryl from FDA and social media. Among them, 19 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

Stay connected: join a mobile support group for people who take Benadryl and have Serotonin syndrome >>>

Benadryl

Benadryl (latest outcomes from 29,318 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) (latest reports from 34,500 patients) has been reported by people with depression, pain, stress and anxiety, major depression, bipolar disorder.

On Jul, 13, 2014: 26,359 people reported to have side effects when taking Benadryl. Among them, 19 people (0.07%) have Serotonin Syndrome. They amount to 0.06% of all the 34,494 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Benadryl reports

Time on Benadryl when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome100.00%0.00%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Serotonin syndrome when taking Benadryl * :

FemaleMale
Serotonin syndrome68.42%31.58%

Age of people who have Serotonin syndrome when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%20.00%0.00%13.33%20.00%20.00%26.67%

Severity of Serotonin syndrome when taking Benadryl ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (8 people, 42.11%)
  2. Atrial fibrillation (3 people, 15.79%)
  3. Insomnia (3 people, 15.79%)
  4. Ill-defined disorder (3 people, 15.79%)
  5. Mood swings (2 people, 10.53%)

Top co-used drugs for these people * :

  1. Zoloft (7 people, 36.84%)
  2. Seroquel (5 people, 26.32%)
  3. Geodon (5 people, 26.32%)
  4. Wellbutrin (4 people, 21.05%)
  5. Zofran (3 people, 15.79%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

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  • I have been having charlie horses for about a month. I also have muscle twitching that started in one leg and within two weeks it has spread to my entire body. my blood work came back normal.

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  • From this study (1 week ago):

  • 27 L knee operations, three massive L knee infections resulting in a third and final arthoplasty revision. Extensive soft tissue damage resulting in perminante subqutanious sutuers and locking full leg brace, also perminante.

    Daily swelling in the knee joint (4 to 6 cm daily). Constant pain as well as additional pain when walking.

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  • From this study (2 weeks ago):

  • Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.

    Reply

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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