Benadryl and Serotonin syndrome - from FDA reports


Serotonin syndrome is found among people who take Benadryl, especially for people who are female, 50-59 old also take medication Zofran, and have Depression. This review analyzes which people have Serotonin syndrome with Benadryl. It is created by eHealthMe based on reports of 44,874 people who have side effects when taking Benadryl from FDA , and is updated regularly.

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On Sep, 19, 2017

44,874 people reported to have side effects when taking Benadryl.
Among them, 39 people (0.09%) have Serotonin syndrome

Number of reports submitted per year:

Could Benadryl cause Serotonin syndrome?

Gender of people who have Serotonin syndrome when taking Benadryl *:

  • female: 79.49 %
  • male: 20.51 %

Age of people who have Serotonin syndrome when taking Benadryl *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 6.45 %
  • 20-29: 0.0 %
  • 30-39: 12.9 %
  • 40-49: 12.9 %
  • 50-59: 45.16 %
  • 60+: 22.58 %

Top conditions involved for these people *:

  • Depression (23 people, 58.97%)
  • Pain (13 people, 33.33%)
  • Stress And Anxiety (10 people, 25.64%)
  • Nausea (8 people, 20.51%)
  • Procedural Pain (7 people, 17.95%)

Top co-used drugs for these people *:

  • Zofran (12 people, 30.77%)
  • Promethazine (11 people, 28.21%)
  • Wellbutrin (10 people, 25.64%)
  • Prozac (10 people, 25.64%)
  • Zoloft (9 people, 23.08%)

Top other side effects for these people *:

  • Nausea (10 people, 25.64%)
  • Agitation (10 people, 25.64%)
  • Nausea And Vomiting (8 people, 20.51%)
  • Feeling Abnormal (8 people, 20.51%)
  • Fall (8 people, 20.51%)

* Approximation only. Some reports may have incomplete information.

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Do you have Serotonin syndrome when taking Benadryl?

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Serotonin syndrome and drugs with ingredients of diphenhydramine hydrochloride.

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Serotonin syndrome and Benadryl from FDA and eHealthMe reports


Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 49,079 users)

Serotonin syndrome

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) has been reported by people with depression, pain, stress and anxiety, major depression, insomnia (latest reports from 10,388 Serotonin syndrome patients).

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