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Review: could Benadryl cause Short-term memory loss?

Summary: Short-term memory loss could be caused by Benadryl, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Aspirin, and have Pain.

We study 26,326 people who have side effects while taking Benadryl from FDA and social media. Among them, 534 have Short-term memory loss. Find out below who they are, when they have Short-term memory loss and more.

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Benadryl

Benadryl (latest outcomes from 29,278 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Short-term memory loss

Short-term memory loss (latest reports from 461,467 patients) has been reported by people with multiple sclerosis, depression, high blood pressure, pain, pain relief by acupuncture.

On Apr, 11, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 534 people (2.04%) have Short-term Memory Loss. They amount to 0.12% of all the 460,775 people who have Short-term Memory Loss on eHealthMe.

Trend of Short-term memory loss in Benadryl reports

Time on Benadryl when people have Short-term memory loss * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Short-term memory loss64.58%2.08%2.08%2.08%8.33%12.50%8.33%

Gender of people who have Short-term memory loss when taking Benadryl * :

FemaleMale
Short-term memory loss64.66%35.34%

Age of people who have Short-term memory loss when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Short-term memory loss0.00%0.21%1.88%5.22%13.36%29.44%16.70%33.19%

Severity of Short-term memory loss when taking Benadryl ** :

leastmoderateseveremost severe
Short-term memory loss9.09%54.55%36.36%0.00%

How people recovered from Short-term memory loss ** :

while on the drugafter off the drugnot yet
Short-term memory loss0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Pain (55 people, 10.30%)
  2. Hypertension (50 people, 9.36%)
  3. Insomnia (37 people, 6.93%)
  4. Multiple sclerosis (35 people, 6.55%)
  5. Depression (33 people, 6.18%)

Top co-used drugs for these people * :

  1. Aspirin (105 people, 19.66%)
  2. Zometa (98 people, 18.35%)
  3. Ambien (90 people, 16.85%)
  4. Neurontin (73 people, 13.67%)
  5. Oxycontin (68 people, 12.73%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Short-term memory loss

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (6 months ago):

  • Left side facial nerve pain due to enlarged cheekbone pressing on 5 th cranial nerve. Believed to have also trigeminal neuralgia type 2 due to procedures in attempts to alleviate cranial nerve pain.
    Diagnosed with pseudoporphyria 2 months ago. Believed to be brought on by nsaid medications. Auto immune diseases not tested for or ruled out.
    Severe anxiety correlates with timing of first symptoms of porphyria

    Reply

  • From this study (2 years ago):

  • ronauda M on Apr, 20, 2012:

    I have insomnia real bad.I was on the geneeric ambien but that stopped working. My doctor perscribed the real ambien, but was way to expensive. My insurance wouldn't cover it. I have been taking over the counter sleep aid for past 2 years. I'm now up to 50mg of diphenhydramine @ 4 pills per night. I started losing my memory,my name at times, ending up walking and not remembering how I got there. I thought it was menopause. Now my new doctor has told me of this sllep aide can cause memory loss. I'm now on trazadone.

    Reply

  • From this study (5 years ago):

  • for me I go to the doctor after I have tried the medicine for about 6 months. Some medicines you take and immediately know that they are working. The side effects that bother me the most is my memory loss and insomnia. The ambien worked like a charm for about the first year that I took it and now three years later, I have added Benadryl to assist with the whole insomnia thing. Doctor reccommended doing this instead of going up to a higher dose of ambien. I've also tried melatonin with little succes. The anti deprssent (Lexapro 10mg) does help my depression a lot, but it leaves me with the chronic "no libido" syndrom.

    Reply

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