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Review: could Benadryl cause Weight gain?

Summary: Weight gain could be caused by Benadryl, especially for people who are female, 30-39 old, have been taking the drug for < 1 month, also take Zyprexa, and have Depression.

We study 26,199 people who have side effects while taking Benadryl from FDA and social media. Among them, 552 have Weight gain. Find out below who they are, when they have Weight gain and more.

On Apr, 11, 2014: 26,199 people reported to have side effects when taking Benadryl. Among them, 552 people (2.11%) have Weight Gain. They amount to 0.11% of all the 520,708 people who have Weight Gain on eHealthMe.

Trend of Weight gain in Benadryl reports

Time on Benadryl when people have Weight gain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight gain40.00%13.33%0.00%6.67%26.67%6.67%6.67%

Gender of people who have Weight gain when taking Benadryl * :

FemaleMale
Weight gain74.30%25.70%

Age of people who have Weight gain when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Weight gain0.44%1.97%7.66%3.06%25.60%25.16%22.10%14.00%

Severity of Weight gain when taking Benadryl ** :

leastmoderateseveremost severe
Weight gain22.22%44.44%22.22%11.11%

How people recovered from Weight gain ** :

while on the drugafter off the drugnot yet
Weight gain0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (74 people, 13.41%)
  2. Hypertension (51 people, 9.24%)
  3. Pain (47 people, 8.51%)
  4. Bipolar disorder (47 people, 8.51%)
  5. Anxiety (44 people, 7.97%)

Top co-used drugs for these people * :

  1. Zyprexa (108 people, 19.57%)
  2. Paxil (85 people, 15.40%)
  3. Seroquel (83 people, 15.04%)
  4. Prilosec (77 people, 13.95%)
  5. Klonopin (73 people, 13.22%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Weight gain

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (3 years ago):

  • I had side effects from statin drugs -- severe muscle and joint pain. Changed to Zetia and my knees hurt so badly that I almost could not get up and down out of a chair. Stopped Zetia and my knee pain disappeared within a few weeks. Have gained approximately 50 lb while on the drugs listed.

    Reply

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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