Review: could Benadryl cause Withdrawal syndrome?
Summary: Withdrawal syndrome is found among people who take Benadryl, especially for people who are female, 40-49 old, have been taking the drug for < 1 month, also take medication Xanax, and have High blood pressure.
We study 26,425 people who have side effects while taking Benadryl from FDA and social media. Among them, 47 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.
You are not alone: join a mobile support group for people who take Benadryl and have Withdrawal syndrome >>>
Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,380 Benadryl users)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) has been reported by people with depression, pain, stress and anxiety, muscle spasticity, back pain. (latest reports from 9,228 Withdrawal syndrome patients)
On Jan, 14, 2015: 26,414 people reported to have side effects when taking Benadryl. Among them, 47 people (0.18%) have Withdrawal Syndrome.
Time on Benadryl when people have Withdrawal syndrome * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years |
|Withdrawal syndrome||50.00%||0.00%||33.33%||0.00%||0.00%||0.00%||16.67% |
Gender of people who have Withdrawal syndrome when taking Benadryl * :
|Withdrawal syndrome||62.50%||37.50% |
Age of people who have Withdrawal syndrome when taking Benadryl * :
|Withdrawal syndrome||0.00%||21.43%||0.00%||0.00%||10.71%||35.71%||10.71%||21.43% |
Severity of Withdrawal syndrome when taking Benadryl ** :
|least||moderate||severe||most severe |
|Withdrawal syndrome||0.00%||0.00%||0.00%||100.00% |
How people recovered from Withdrawal syndrome ** :
|while on the drug||after off the drug||not yet |
|Withdrawal syndrome||0.00%||100.00%||0.00% |
Top conditions involved for these people * :
- Hypertension (20 people, 42.55%)
- Depression (19 people, 40.43%)
- Breast cancer (16 people, 34.04%)
- Metastases to bone (16 people, 34.04%)
- Diabetes mellitus (16 people, 34.04%)
Top co-used drugs for these people * :
- Xanax (21 people, 44.68%)
- Reglan (20 people, 42.55%)
- Ibuprofen (18 people, 38.30%)
- Hydrochlorothiazide (17 people, 36.17%)
- Promethazine (17 people, 36.17%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Withdrawal Syndrome while taking Benadryl?
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- support group for people who take Benadryl and have Withdrawal Syndrome
- support group for people who take Benadryl
- support group for people who have Withdrawal Syndrome
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- Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
- Nightmare on benadryl
After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
- Benadryl completed suicide 50 year old
My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
- Lorazepam nearly killed me during cancer treatment
Day 31 of cold turkey and I want to die. It is a roller coaster from body tics and sweats to rage and crying in one day. I felt so good the 4h day of c/t. It was like before my cancer diagnosis. My bowels are better off Lorazepam. I threw up during bowel movements from the pain. Off Lorazepam first normal bowel movement in over 2 years. Stomach so damaged by Lorazepam that I have absolutely no appetite. I force myself to eat. Neuropathy in hands nearly gone. Feet are better but slower. Lymphedema that appeared after one year on Lorazepam is now gone. I have full range of motion.
- Had nms in 2005, will trileptal increase chance of recurrence?
In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
More reviews for: Benadryl, Withdrawal syndrome
Comments from related studies:
From this study (2 years ago):
The length of time I've struggled with sleep disorders has resulted in higher than normal Benadryl usage, but I wake up every day (after only a few hours of sleep) with my ears feeling plugged now. Benadryl is the only thing I have found to relieve the pressure, increasing my usage of the drug even more.
NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
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