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Review: could Benadryl cause Withdrawal syndrome?

We study 26,370 people who have side effects while taking Benadryl from FDA and social media. Among them, 47 have Withdrawal syndrome. Find out below who they are, when they have Withdrawal syndrome and more.

Stay connected: join a mobile support group for people who take Benadryl and have Withdrawal syndrome >>>

Benadryl

Benadryl (latest outcomes from 29,327 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergen.

Withdrawal syndrome

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) (latest reports from 56,367 patients) has been reported by people with depression, pain, stress and anxiety, muscle spasticity, back pain.

On Aug, 11, 2014: 26,364 people reported to have side effects when taking Benadryl. Among them, 47 people (0.18%) have Withdrawal Syndrome. They amount to 0.08% of all the 56,357 people who have Withdrawal Syndrome on eHealthMe.

Trend of Withdrawal syndrome in Benadryl reports

Time on Benadryl when people have Withdrawal syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Withdrawal syndrome50.00%0.00%33.33%0.00%0.00%0.00%16.67%

Gender of people who have Withdrawal syndrome when taking Benadryl * :

FemaleMale
Withdrawal syndrome62.50%37.50%

Age of people who have Withdrawal syndrome when taking Benadryl * :

0-12-910-1920-2930-3940-4950-5960+
Withdrawal syndrome0.00%21.43%0.00%0.00%10.71%35.71%10.71%21.43%

Severity of Withdrawal syndrome when taking Benadryl ** :

leastmoderateseveremost severe
Withdrawal syndrome0.00%0.00%0.00%100.00%

How people recovered from Withdrawal syndrome ** :

while on the drugafter off the drugnot yet
Withdrawal syndrome0.00%100.00%0.00%

Top conditions involved for these people * :

  1. Hypertension (20 people, 42.55%)
  2. Depression (19 people, 40.43%)
  3. Breast cancer (16 people, 34.04%)
  4. Metastases to bone (16 people, 34.04%)
  5. Diabetes mellitus (16 people, 34.04%)

Top co-used drugs for these people * :

  1. Xanax (21 people, 44.68%)
  2. Reglan (20 people, 42.55%)
  3. Ibuprofen (18 people, 38.30%)
  4. Hydrochlorothiazide (17 people, 36.17%)
  5. Promethazine (17 people, 36.17%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Benadryl and have Withdrawal Syndrome
- group for people who take Benadryl
- group for people who have Withdrawal Syndrome

Comments from related studies:

  • From this study (2 years ago):

  • The length of time I've struggled with sleep disorders has resulted in higher than normal Benadryl usage, but I wake up every day (after only a few hours of sleep) with my ears feeling plugged now. Benadryl is the only thing I have found to relieve the pressure, increasing my usage of the drug even more.

    Reply

Can you answer these questions (what is this?):

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On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used for allergies. Find out below the conditions Benadryl is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Benadryl used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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