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Review: could Carboplatin cause Anaphylaxis?

Summary: Anaphylaxis is found among people who take Carboplatin, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take medication Taxol, and have Ovarian cancer.

We study 28,842 people who have side effects while taking Carboplatin from FDA and social media. Among them, 271 have Anaphylaxis. Find out below who they are, when they have Anaphylaxis and more.

You are not alone: join a mobile support group for people who take Carboplatin and have Anaphylaxis >>>

 

 

 

 

Carboplatin

Carboplatin has active ingredients of carboplatin. It is often used in cancer. (latest outcomes from 28,931 Carboplatin users)

Anaphylaxis

Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death) has been reported by people with multiple sclerosis, asthma, high blood pressure, premedication, pain. (latest reports from 28,935 Anaphylaxis patients)

On Feb, 1, 2015: 28,842 people reported to have side effects when taking Carboplatin. Among them, 271 people (0.94%) have Anaphylaxis.

Trend of Anaphylaxis in Carboplatin reports

Time on Carboplatin when people have Anaphylaxis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Anaphylaxis82.18%14.85%0.99%0.99%0.99%0.00%0.00%

Gender of people who have Anaphylaxis when taking Carboplatin * :

FemaleMale
Anaphylaxis75.61%24.39%

Age of people who have Anaphylaxis when taking Carboplatin * :

0-12-910-1920-2930-3940-4950-5960+
Anaphylaxis0.42%2.93%0.84%1.26%2.09%5.86%31.80%54.81%

Severity of Anaphylaxis when taking Carboplatin ** :

leastmoderateseveremost severe
Anaphylaxis0.00%100.00%0.00%0.00%

How people recovered from Anaphylaxis ** :

while on the drugafter off the drugnot yet
Anaphylaxis100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Ovarian cancer (70 people, 25.83%)
  2. Non-small cell lung cancer (25 people, 9.23%)
  3. Breast cancer (10 people, 3.69%)
  4. Hypersensitivity (9 people, 3.32%)
  5. Lung neoplasm malignant (9 people, 3.32%)

Top co-used drugs for these people * :

  1. Taxol (65 people, 23.99%)
  2. Paclitaxel (55 people, 20.30%)
  3. Dexamethasone (33 people, 12.18%)
  4. Zantac (31 people, 11.44%)
  5. Decadron (27 people, 9.96%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Anaphylaxis while taking Carboplatin?

You are not alone! Join a mobile support group:
- support group for people who take Carboplatin and have Anaphylaxis
- support group for people who take Carboplatin
- support group for people who have Anaphylaxis

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

  • Seizure after an epipen injection (1 answer)
    I am allergic to EVERYTHING, so I usually pre-game with benadryl and wait out the uncomfortable side effects, but this time my tongue started swelling up and I was having trouble breathing so I went to an ER. About 5-7 minutes after they injected me in the thigh with an epipen, I was in mid sentence when I started having strange sensations and tremors all over my body. The injection spot, which is incredibly sore and feels like they hit my femur) suddenly became very warm and I could feel it spreading out quickly. I could hear people but I couldn't speak, everything clamped up, I couldn't breathe and I felt very confused and forgot what I was about to say to the nurse. The doctor caught the tail end of it and claimed I was having a panic attack! I heard both the nurses say that they thought it was a seizure. This happened to me once more a few yrs ago with an allergic reaction, but it was from the nurse pushing in the benadryl too quickly, which made my hands curl up like T-Rex and my eyes rolled back into my head. Is there such a thing as being allergic to epinephrine or has anyone ever experienced a seizure/stroke like reaction after being administered Epipen or Benadryl ?
  • Can r-chop chemotherapy cause aortic stenosis?
    Treated with 3 courses of R-CHOP plus radiotherapy for Diffuse large B-cell lymphoma of orbit of eye in 2010. In complete remission until 2014 then relapse of genetically identical tumor in maxillary sinus. Recently have received 3 courses of R-ICE. During the past week I have had a cardiac ECHO which showed aortic stenosis. I also had an episode of hypotension and bradycardia lasting about a day during one the RICE treatments.
  • Can thyroid problems bring on anaphylaxis often?
    70 yr old previously stong female: Suspicious of thyroid problems...family history. Fatigue, skin, hair changes, slightly swollen, tender tongue at all times. In the last 6 months I've developed food related anaphalaxis. Getting serious, 3 E.R. runs in last 3 months....packing 2 epipens at all times. Endocrinologist apt not until mid December. I can't seem to stay clear of anaphalaxis long enough to get to the Allergist's for those blood tests.

    Any one else gone this route?
  • Should a 66-year-old with paroxysmal atrial tachycardia (pat) take herceptin for 6 months instread of 12 months?
    My concern is the potential for cardiac damage from taking Herceptin. The research on Herceptin for highly HER2 positive breast cancer seems less than clear that 12 months of treatment has truly significant benefit over 6 months. With a pre-existing heart condition of PAT (rx metoprolol) and also high blood pressure (rx losartan) would it be more prudent to limit the Herceptin to 6 mos?
  • Does avastin in conjunction with gemcitabine and carboplatin cause a danger to persons who had a bone marrow transplant (their own marrow)?
    after taking the series of carboplatin and taxol combination, the ca 125 numbers hat had reached a low of in the 20's had rebounded to the 50's.

    Also, the neuropathy in the right hand and foot had reached a serious stage.

    At this point, the md decided to change the regimen to gemcitabine and carboplatin, but refuses to also give avastin as this might affect the brain negatively because of the previous bone marrow transplant.

More questions for: Carboplatin, Anaphylaxis

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More reviews for: Carboplatin, Anaphylaxis

Comments from related studies:

  • From this study (2 months ago):

  • I had 2 anaphylactic responses within three weeks of each other and I am looking for a common element. I had taken it before but prn. Then I had rotator cuff surgery and took it while away and reacted within an hr and didn't take one again until yesterday and within an hour I was back in emergency. The only common food factor other then this drug was chicken. I am pursuing, diligently to figure this out.

    Reply

  • From this study (3 months ago):

  • Was on Cymbalta 30mg for around 3 weeks and was increased to 60mg. Three days after beginning 60mg dosage, I went into Anaphylactic Shock. First my eyes were sensitive to light and I had brain fog. The following day, I thought I was beginning to feel better and in the middle of a store, the right side of my face drew up as if I were having a stroke and tongue swollen out of mouth and airways were blocked. My mother rushed me to the hospital where they diagnosed me with Anaphylactic shock, was in CCU for a couple of days with IVs and several EpiPens later and a couple of days in a regular hospital room with several other shock episodes in between. I almost died.

    Reply

  • From this study (4 months ago):

  • since having 2 episodes so far this year which nobody knows what caused them. i suffer with my breathing and have chest pains. i never had these before the shock

    Reply

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