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Review: could Clonazepam cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Clonazepam, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Lorazepam, and have Depression.

We study 38,594 people who have side effects while taking Clonazepam from FDA and social media. Among them, 284 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

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On Apr, 10, 2014: 38,552 people reported to have side effects when taking Clonazepam. Among them, 284 people (0.74%) have Serotonin Syndrome. They amount to 0.83% of all the 34,358 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Clonazepam reports

Time on Clonazepam when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome3.45%89.66%3.45%0.00%3.45%0.00%0.00%

Gender of people who have Serotonin syndrome when taking Clonazepam * :

Serotonin syndrome69.31%30.69%

Age of people who have Serotonin syndrome when taking Clonazepam * :

Serotonin syndrome0.00%0.36%3.56%11.03%21.35%24.20%13.17%26.33%

Severity of Serotonin syndrome when taking Clonazepam ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%0.00%100.00%0.00%

How people recovered from Serotonin syndrome ** :

while on the drugafter off the drugnot yet
Serotonin syndrome0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Depression (82 people, 28.87%)
  2. Anxiety (28 people, 9.86%)
  3. Neck pain (28 people, 9.86%)
  4. Sedation (24 people, 8.45%)
  5. Post-traumatic stress disorder (23 people, 8.10%)

Top co-used drugs for these people * :

  1. Lorazepam (70 people, 24.65%)
  2. Omeprazole (66 people, 23.24%)
  3. Paroxetine hcl (63 people, 22.18%)
  4. Diazepam (49 people, 17.25%)
  5. Quetiapine (48 people, 16.90%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

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Related topic: Clonazepam, Serotonin syndrome

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On eHealthMe, Clonazepam (clonazepam) is often used for stress and anxiety. Find out below the conditions Clonazepam is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Clonazepam used for and how effective is it:

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Comments from related studies:

  • From this study (13 months ago):

  • I wake up and feel like I'm going through withdrawals, take my Pristiq & unfortunately Ritalin (because if I don't I am physically ill for days).. anyway, sometimes after I take my morning pills I feel better, sometimes I don't. I'm always tired and yet even with my sleep pills I cannot fall asleep. I hate this medicated life. I want off this junk, but don't know how!


  • From this study (2 years ago):

  • I have not added any new meds extremely recently. Started taking Vyvanse 6 months ago, but I feel I have quite severe serotonin syndrome on and off recently. That may NOT be what it is, symptoms over the past few weeks are extreme jolts of hard to explain type of electricity. Just constant jolting feeling with every step. But not while sitting down AT ALL. Maybe even a touch of dizziness or vertigo feeling.


  • From this study (2 years ago):

  • I wanted to check for serotonin syndrome. I take the adderall to stay awake from pain medicine which helps, but also worries me.


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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