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Review: could Cymbalta cause Leg swelling (Foot, leg, and ankle swelling)?

Summary: Leg swelling is found among people who take Cymbalta, especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months, also take medication Vitamin d, and have Depression.

We study 45,751 people who have side effects while taking Cymbalta from FDA and social media. Among them, 17 have Leg swelling. Find out below who they are, when they have Leg swelling and more.

You are not alone: join a mobile support group for people who take Cymbalta and have Leg swelling >>>

 

 

 

 

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from 49,355 Cymbalta users)

Leg swelling

Leg swelling has been reported by people with high blood pressure, depression, high blood cholesterol, gastroesophageal reflux disease, hypothyroidism. (latest reports from 1,420 Leg swelling patients)

On Feb, 27, 2015: 45,751 people reported to have side effects when taking Cymbalta. Among them, 18 people (0.04%) have Leg Swelling.

Trend of Leg swelling in Cymbalta reports

Time on Cymbalta when people have Leg swelling * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Leg swelling11.76%29.41%11.76%11.76%23.53%11.76%0.00%

Age of people who have Leg swelling when taking Cymbalta * :

0-12-910-1920-2930-3940-4950-5960+
Leg swelling0.00%0.00%0.00%5.56%22.22%16.67%38.89%16.67%

Severity of Leg swelling when taking Cymbalta ** :

leastmoderateseveremost severe
Leg swelling0.00%33.33%50.00%16.67%

How people recovered from Leg swelling ** :

while on the drugafter off the drugnot yet
Leg swelling0.00%14.29%85.71%

Top conditions involved for these people * :

  1. Depression (9 people, 50.00%)
  2. Pain (2 people, 11.11%)
  3. Rheumatoid arthritis (2 people, 11.11%)
  4. Vitamin d deficiency (2 people, 11.11%)
  5. Fluid retention (2 people, 11.11%)

Top co-used drugs for these people * :

  1. Vitamin d (5 people, 27.78%)
  2. Prednisone (3 people, 16.67%)
  3. Lipitor (2 people, 11.11%)
  4. Topamax (2 people, 11.11%)
  5. Bumex (2 people, 11.11%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Leg Swelling while taking Cymbalta?

You are not alone! Join a mobile support group:
- support group for people who take Cymbalta and have Leg Swelling
- support group for people who take Cymbalta
- support group for people who have Leg Swelling

Recent conversations of related support groups:

  • Support group for people who take Cymbalta
    Now found out I have incompetent vein in leg which may be part of the problem had cystocopy and found cysts in kidney, then developed hypertension but no one will diagnose the pain. Now decided it is the same as diabetic neuropathy but as gp and consultant point out I am a long way from being diabetic with perfect blood glucose so thinks it's just guessing and hope

Drugs in real world that are associated with:

Could your condition cause:

Can you answer these questions (Ask a question):

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  • Do i need to quit drinking coffee while i take thrive?
    I take Cymbalta for pain relief from Arthritis and now on Metformin due to Diabetes 2 probably from lack of exercise because of the Arthritis pain. I am 70 years old and just started taking Thrive. I drink coffee a cup of coffee in the morning each day. Do I need to stop that habit?

    Are there other "oldies" out there taking Thrive? Please tell me your results with it. Thanks
  • Can combo of subutex and carfate cause joint pain (1 answer)
    I am taking Carafate and Nexium for the treatment of several stomach ulcers. In addition I am on Subutex for maintenance of opiate dependence. I am having severe joint pain with this combination. Has anyone else had this situation or reaction?
  • I have been on amlodipine for approximately 3 months and have had terrible swelling in my legs and ankles along with pain and itching. should i be taken off this medication?
    I was previously taking Propranolol for blood pressure which didn't bother me at all, but last year I developed a breathing problem and was given Symbicort to help get rid of wheezing. The Symbicort and Propranolol don't mesh well so I was then put on Amlodipine. The swelling, pain and itching occurred right away. I asked the pharmacist about it and also my doctor and they both said a small percentage of people have this problem on this medication. I have tried many times to get my doctor to take me off of this medication but he insists it is best for me, but I disagree. I really don't want to have this problem for the rest of my life and I also won't have any skin left on my legs from the scratching, not to mention the pain that accompanies the swelling which seem to creep up to my knees and thighs and sometimes is so painful I just go to bed to lay down and hopefully the hydroclorithiazide will remove some of this water so that pain will go away. The doctor also doubled my dose of Losartin and Hydroclorithiazide. I'm up about 4-6 times a night going to the bathroom so it also interrupts my sleep. Is anyone else having this problem. I would prefer to go back on the Propranolol and get something other than Symbicort that won't interact with each other. Then I won't have pain and itching all the time. Does anyone have any input on this. I would really appreciate it.

    Thanks. Debbie CB

More questions for: Cymbalta, Leg swelling

You may be interested at these reviews (Write a review):

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    Actually, I was taking DiMethylFumarate capsules made by a pharmacy since 2 years (Jan 2013-Dec 2014). Switched to Tecfidera before Xmas 2014 and two weeks later I noticed unexplainable pain in my left ankle. The pain appears and disappears rather randomly, it is always only the left leg (I had a serious bone break of my right ankle some 23 years ago, so it was really strange that the pain is only in the left one). Later I realized, that the pain gets stronger in the afternoon/evening. And then noticed, that my left ankle is swollen.
  • Terrible excessive sweating from hydrochlorothiazide
    I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
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More reviews for: Cymbalta, Leg swelling

Comments from related studies:

  • From this study (1 year ago):

  • Hemoglobin level was 7.4 in September, now at 8.6. Had gastric bypass in 2002, with no previous anemia issues.

    Reply

  • From this study (2 years ago):

  • I was in a MVA 2 1/2 years ago, I was an RN and was left unable to work. 3 months after the MVA I underwent a Hysterectomy found 4th grade Endometriosis with Adhesions. Only able to remove uterus, cervix is stuck to bowel unable to remove both ovaries retained. Underwent 2 rounds of 6 months each of Depro Lupron injections endometriosis symptoms subsided for 6-8 months and has since returned being cyclic for 12-15 days a month. During the time between the mva and hysterectomy 2 week period of stiffness, unable to move easily sent to rhuematologist found to recently had Parvo Recovered from that. Over time Rheumatologist diagnosed with connective tissue disorder started on Plaquenil and Prednisone. Diagnosed with Fibromyalgia. Sent to pain management diagnosed with pelvic floor tension myalgia, vuvlodynia, vaginal spasms, low testosterone and intersticial cystitis. Sent to sexual medicine doctor, found muscle damage from hysterectomy did trigger point injections and physical therapy deep tissue massage. Then I tore ACL and Medial Meniscus, unable to continue with pelvic pain doctor because gait was messing up what they were fixing. routine blood test found K+ to be 2.5 started on supplements of 40 meq a day of K+. Total body swelling started overnight started on Lasix, no improvement changed to Bumex edema decreased, potassium increased to 60 meq a day. I have been on pain medication since the MVA I have gone from Vicodin, valium to Percocet oxicontin, to MS Contin, Methadone, Butrans Patch and Now I am on Exalgo 12 mg once a day with 2 mg of dilaudid at bedtime. This does not seem to be working. I have constant abdominal/pelvic pain, vaginal spasms, bladder pain, kidney pain after the Bumex has worn off. I have developed Peripheral Neuropathy of my feet from taking crestor and hydroxychloroquine together, then they changed me to Lipitor, which is a statin and will do the same, Primary MD disagrees. I have suffered from Depression, anxiety, Panic attacks and migraines for over 10 years these are inherited conditions in Maternal Grandmother and Mother, migraines in Father also. They are now looking at Sjogrens Syndrome. Was on Vitamin B6 new medical journals say women should not take more than 10-50 mg a day-otc bottles say 100mg so pain management said I am suffering from vitamin B3 overdose and serotonin syndrome, trying to cut back on anti depressives and anti anxiety meds, but now is not really the time to do, I have been turned down for disability X2

    Reply

    Priti on May, 7, 2013:

    Become a vegan, leave animal protein, do yoga and chant " Nam myoho renge Kyo". Search the website "Soka Gakkai International" , practice this philosophy and see the results.

    Reply

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