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Review: could Cymbalta cause Restless leg?

Summary: Restless leg could be caused by Cymbalta, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Neurontin, and have Depression.

We study 45,578 people who have side effects while taking Cymbalta from FDA and social media. Among them, 317 have Restless leg. Find out below who they are, when they have Restless leg and more.

How are my drugs for patients like me? On eHealthMe, you can research 300 million drug outcomes from FDA and social media. All studies are personalized to gender and age. Start now, it's anonymous, simple & free >>>

Cymbalta

Cymbalta (latest outcomes from 48,967 users) has active ingredients of duloxetine hydrochloride. It is often used in depression.

Restless leg

Restless leg (a powerful urge to move your legs) (latest reports from 68,103 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Apr, 14, 2014: 45,578 people reported to have side effects when taking Cymbalta. Among them, 317 people (0.70%) have Restless Leg. They amount to 0.47% of all the 67,387 people who have Restless Leg on eHealthMe.

Trend of Restless leg in Cymbalta reports

Time on Cymbalta when people have Restless leg * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless leg23.94%12.68%9.86%12.68%32.39%7.04%1.41%

Age of people who have Restless leg when taking Cymbalta * :

0-12-910-1920-2930-3940-4950-5960+
Restless leg0.00%0.00%0.80%3.59%14.74%18.33%30.68%31.87%

Severity of Restless leg when taking Cymbalta ** :

leastmoderateseveremost severe
Restless leg0.00%32.00%52.00%16.00%

How people recovered from Restless leg ** :

while on the drugafter off the drugnot yet
Restless leg0.00%22.22%77.78%

Top conditions involved for these people * :

  1. Depression (103 people, 32.49%)
  2. Pain (50 people, 15.77%)
  3. Restless legs syndrome (50 people, 15.77%)
  4. Sleep disorder (39 people, 12.30%)
  5. Muscle spasms (36 people, 11.36%)

Top co-used drugs for these people * :

  1. Neurontin (92 people, 29.02%)
  2. Ambien (81 people, 25.55%)
  3. Lexapro (75 people, 23.66%)
  4. Zometa (62 people, 19.56%)
  5. Prilosec (59 people, 18.61%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Cymbalta, Restless leg

You can also:

On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used for depression. Find out below the conditions Cymbalta is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Cymbalta used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (3 months ago):

  • I have been told and read in the instructions given by the pharmacy that restless legs can be a side effect of Cymbalta. Cymbalta works great for my neuropathy and depression, but the restless legs every night for a couple of hours is bad.

    Reply

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