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Review: could Cymbalta cause Restless leg syndrome?

Summary: Restless leg syndrome could be caused by Cymbalta, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take Neurontin, and have Depression.

We study 45,418 people who have side effects while taking Cymbalta from FDA and social media. Among them, 317 have Restless leg syndrome. Find out below who they are, when they have Restless leg syndrome and more.

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Cymbalta

Cymbalta (latest outcomes from 48,967 users) has active ingredients of duloxetine hydrochloride. It is often used in depression.

Restless leg syndrome

Restless leg syndrome (a powerful urge to move your legs) (latest reports from 67,448 patients) has been reported by people with osteoporosis, depression, high blood pressure, pain, stress and anxiety.

On Apr, 10, 2014: 45,578 people reported to have side effects when taking Cymbalta. Among them, 317 people (0.70%) have Restless Leg Syndrome. They amount to 0.47% of all the 67,325 people who have Restless Leg Syndrome on eHealthMe.

Trend of Restless leg syndrome in Cymbalta reports

Time on Cymbalta when people have Restless leg syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless leg syndrome23.94%12.68%9.86%12.68%32.39%7.04%1.41%

Age of people who have Restless leg syndrome when taking Cymbalta * :

0-12-910-1920-2930-3940-4950-5960+
Restless leg syndrome0.00%0.00%0.80%3.59%14.74%18.33%30.68%31.87%

Severity of Restless leg syndrome when taking Cymbalta ** :

leastmoderateseveremost severe
Restless leg syndrome0.00%32.00%52.00%16.00%

How people recovered from Restless leg syndrome ** :

while on the drugafter off the drugnot yet
Restless leg syndrome0.00%22.22%77.78%

Top conditions involved for these people * :

  1. Depression (103 people, 32.49%)
  2. Pain (50 people, 15.77%)
  3. Restless legs syndrome (50 people, 15.77%)
  4. Sleep disorder (39 people, 12.30%)
  5. Muscle spasms (36 people, 11.36%)

Top co-used drugs for these people * :

  1. Neurontin (92 people, 29.02%)
  2. Ambien (81 people, 25.55%)
  3. Lexapro (75 people, 23.66%)
  4. Zometa (62 people, 19.56%)
  5. Prilosec (59 people, 18.61%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Cymbalta, Restless leg syndrome

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On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used for depression. Find out below the conditions Cymbalta is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Cymbalta used for and how effective is it:

Other drugs that are used to treat the same conditions:

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Comments from related studies:

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (3 months ago):

  • I have been told and read in the instructions given by the pharmacy that restless legs can be a side effect of Cymbalta. Cymbalta works great for my neuropathy and depression, but the restless legs every night for a couple of hours is bad.

    Reply

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