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Review: could Cymbalta cause Restless legs (Restless Leg Syndrome)?

We study 45,625 people who have side effects while taking Cymbalta from FDA and social media. Among them, 321 have Restless legs. Find out below who they are, when they have Restless legs and more.

Get connected: join a mobile support group for people who take Cymbalta and have Restless legs >>>

Cymbalta

Cymbalta (latest outcomes from 49,191 users) has active ingredients of duloxetine hydrochloride. It is often used in depression.

Restless legs

Restless legs (a powerful urge to move your legs) (latest reports from 67,388 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Sep, 20, 2014: 45,572 people reported to have side effects when taking Cymbalta. Among them, 321 people (0.70%) have Restless Legs.

Trend of Restless legs in Cymbalta reports

Time on Cymbalta when people have Restless legs * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs22.67%13.33%9.33%12.00%32.00%8.00%2.67%

Age of people who have Restless legs when taking Cymbalta * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs0.00%0.00%0.78%3.92%14.51%19.22%30.20%31.37%

Severity of Restless legs when taking Cymbalta ** :

leastmoderateseveremost severe
Restless legs0.00%31.03%48.28%20.69%

How people recovered from Restless legs ** :

while on the drugafter off the drugnot yet
Restless legs0.00%19.05%80.95%

Top conditions involved for these people * :

  1. Depression (107 people, 33.33%)
  2. Restless legs syndrome (50 people, 15.58%)
  3. Pain (50 people, 15.58%)
  4. Sleep disorder (40 people, 12.46%)
  5. Muscle spasms (36 people, 11.21%)

Top co-used drugs for these people * :

  1. Neurontin (92 people, 28.66%)
  2. Ambien (81 people, 25.23%)
  3. Lexapro (75 people, 23.36%)
  4. Zometa (62 people, 19.31%)
  5. Prilosec (59 people, 18.38%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Restless Legs while taking Cymbalta?

Get connected! Join a mobile support group:
- group for people who take Cymbalta and have Restless Legs
- group for people who take Cymbalta

Comments from related studies:

  • From this study (4 months ago):

  • tired all the time. My muscles ache and I constantly clench my teeth -currently I am wearing a splint given to me by an oral surgeon. --I feel older than I am. A lot older.

    Reply

  • From this study (7 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (7 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

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On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used for depression. Find out below the conditions Cymbalta is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Cymbalta used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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