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Review: could Depakote cause Autism?

Summary: Autism is found among people who take Depakote, especially for people who are male, 10-19 old, also take medication Seroquel, and have Depression.

We study 29,629 people who have side effects while taking Depakote from FDA and social media. Among them, 29 have Autism. Find out below who they are, when they have Autism and more.

You are not alone: join a support group for people who take Depakote and have Autism >>>



Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,959 Depakote users)


Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts) has been reported by people with depression, stress and anxiety, epilepsy, convulsion, attention deficit hyperactivity disorder. (latest reports from 1,722 Autism patients)

On Apr, 4, 2015: 29,624 people reported to have side effects when taking Depakote. Among them, 29 people (0.10%) have Autism.

Trend of Autism in Depakote reports

Time on Depakote when people have Autism * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Autism when taking Depakote * :


Age of people who have Autism when taking Depakote * :


Severity of Autism when taking Depakote ** :


How people recovered from Autism ** :


Top conditions involved for these people * :

  1. Depression (13 people, 44.83%)
  2. Impulsive behaviour (10 people, 34.48%)
  3. Attention deficit/hyperactivity disorder (10 people, 34.48%)
  4. Rhinitis allergic (10 people, 34.48%)
  5. Autism (10 people, 34.48%)

Top co-used drugs for these people * :

  1. Seroquel (16 people, 55.17%)
  2. Paxil (13 people, 44.83%)
  3. Lorazepam (12 people, 41.38%)
  4. Risperdal (12 people, 41.38%)
  5. Ambien (10 people, 34.48%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of depakote and autism on

Do you have Autism while taking Depakote?




You are not alone! Join a support group on :
- support group for people who take Depakote and have Autism
- support group for people who take Depakote
- support group for people who have Autism

Drugs in real world that are associated with:

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Recent Depakote related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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