Review: could Depakote cause Autism?


Autism is found among people who take Depakote, especially for people who are male, 2-9 old , have been taking the drug for 10+ years, also take medication Paxil, and have Depression . We study 29,120 people who have side effects while taking Depakote from FDA and social media. Among them, 40 have Autism. Find out below who they are, when they have Autism and more.

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Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 33,660 users)


Autism (a mental condition, present from early childhood, characterized by difficulty in communicating and forming relationships with other people and in using language and abstract concepts) has been reported by people with pseudotumor cerebri, drowsiness, insomnia, blood prolactin increased, stress and anxiety (latest reports from 1,976 Autism patients).

On Aug, 26, 2016

29,120 people reported to have side effects when taking Depakote.
Among them, 40 people (0.14%) have Autism

Number of reports submitted per year:

Could Depakote cause Autism?

Time on Depakote when people have Autism *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 18.18 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 81.82 %

Gender of people who have Autism when taking Depakote *:

  • female: 32.43 %
  • male: 67.57 %

Age of people who have Autism when taking Depakote *:

  • 0-1: 0.0 %
  • 2-9: 58.33 %
  • 10-19: 41.67 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  • Depression (13 people)
  • Epilepsy (5 people)
  • Abnormal Behaviour (4 people)
  • Migraine (2 people)
  • Drug Exposure During Pregnancy (2 people)

Top co-used drugs for these people *:

  • Paxil (13 people)
  • Terbutaline Sulfate (8 people)
  • Seroquel (8 people)
  • Tylenol (6 people)
  • Serax (6 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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