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Review: could Depakote cause Muscle spasms?

We study 29,591 people who have side effects while taking Depakote from FDA and social media. Among them, 247 have Muscle spasms. Find out below who they are, when they have Muscle spasms and more.

Get connected: join a mobile support group for people who take Depakote and have Muscle spasms >>>


Depakote (latest outcomes from 30,913 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

Muscle spasms

Muscle spasms (muscle contraction) (latest reports from 350,227 patients) has been reported by people with multiple sclerosis, high blood cholesterol, osteoporosis, high blood pressure, pain.

On Sep, 21, 2014: 29,588 people reported to have side effects when taking Depakote. Among them, 247 people (0.83%) have Muscle Spasms.

Trend of Muscle spasms in Depakote reports

Time on Depakote when people have Muscle spasms * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Muscle spasms33.33%8.33%33.33%0.00%16.67%8.33%0.00%

Gender of people who have Muscle spasms when taking Depakote * :

Muscle spasms71.81%28.19%

Age of people who have Muscle spasms when taking Depakote * :

Muscle spasms0.00%0.00%3.27%6.07%21.96%34.11%20.56%14.02%

Severity of Muscle spasms when taking Depakote ** :

leastmoderateseveremost severe
Muscle spasms0.00%0.00%100.00%0.00%

How people recovered from Muscle spasms ** :

while on the drugafter off the drugnot yet
Muscle spasms100.00%0.00%0.00%

Top conditions involved for these people * :

  1. Pain (69 people, 27.94%)
  2. Bipolar disorder (59 people, 23.89%)
  3. Depression (43 people, 17.41%)
  4. Headache (34 people, 13.77%)
  5. Anxiety (33 people, 13.36%)

Top co-used drugs for these people * :

  1. Seroquel (63 people, 25.51%)
  2. Zyprexa (52 people, 21.05%)
  3. Depakote er (48 people, 19.43%)
  4. Xanax (47 people, 19.03%)
  5. Zoloft (46 people, 18.62%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Muscle Spasms while taking Depakote?

Get connected! Join a mobile support group:
- group for people who take Depakote and have Muscle Spasms
- group for people who take Depakote
- group for people who have Muscle Spasms

Comments from related studies:

  • From this study (9 months ago):

  • The only drug I stopped taking was Zofran, which was given to me via IV push to prevent severe nausea associated with IVIG infusion (Privigen) . All others, including mestinon, were continued.


  • From this study (4 years ago):

  • Kelly on Apr, 15, 2010:

    I am being prescribed these drugs together. I have a few concerns, one is weight gain? I could hide 10 but after that...Dry mouth which is annoying. and the third is the Asthenia. Combined I don't want people to think I am drunk, but I still want people to know I finally feel better and can complete a thought and complete a task without having to be reminded. Thank you for your bravery and comment to me if you want I need eople who are where I am in this and it is pretty family isn't receptive, my husband is because he sees me every day. Thanks for listening.


Can you answer these questions (what is this?):

More questions for: Depakote, Muscle spasms

You may be interested at these reviews (what is this?):

  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefrui ...

More reviews for: Depakote, Muscle spasms

On eHealthMe, Depakote (divalproex sodium) is often used for bipolar disorder. Find out below the conditions Depakote is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Depakote used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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