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Review: could Depakote cause Restless legs syndrome?

We study 29,579 people who have side effects while taking Depakote from FDA and social media. Among them, 88 have Restless legs syndrome. Find out below who they are, when they have Restless legs syndrome and more.

Stay connected: join a mobile support group for people who take Depakote and have Restless legs syndrome >>>

Depakote

Depakote (latest outcomes from 30,897 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

Restless legs syndrome

Restless legs syndrome (a powerful urge to move your legs) (latest reports from 68,568 patients) has been reported by people with restless leg syndrome, osteoporosis, depression, high blood pressure, pain.

On Jul, 15, 2014: 29,576 people reported to have side effects when taking Depakote. Among them, 88 people (0.30%) have Restless Legs Syndrome. They amount to 0.13% of all the 68,510 people who have Restless Legs Syndrome on eHealthMe.

Trend of Restless legs syndrome in Depakote reports

Time on Depakote when people have Restless legs syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Restless legs syndrome0.00%14.29%0.00%14.29%28.57%14.29%28.57%

Gender of people who have Restless legs syndrome when taking Depakote * :

FemaleMale
Restless legs syndrome73.47%26.53%

Age of people who have Restless legs syndrome when taking Depakote * :

0-12-910-1920-2930-3940-4950-5960+
Restless legs syndrome0.00%0.00%3.53%5.88%8.24%30.59%50.59%1.18%

Severity of Restless legs syndrome when taking Depakote ** :

leastmoderateseveremost severe
Restless legs syndrome0.00%20.00%60.00%20.00%

How people recovered from Restless legs syndrome ** :

while on the drugafter off the drugnot yet
Restless legs syndrome0.00%25.00%75.00%

Top conditions involved for these people * :

  1. Bipolar disorder (33 people, 37.50%)
  2. Pain (18 people, 20.45%)
  3. Depression (17 people, 19.32%)
  4. Anxiety (15 people, 17.05%)
  5. Hypomania (14 people, 15.91%)

Top co-used drugs for these people * :

  1. Seroquel (46 people, 52.27%)
  2. Geodon (28 people, 31.82%)
  3. Risperdal (27 people, 30.68%)
  4. Zyprexa (25 people, 28.41%)
  5. Neurontin (24 people, 27.27%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 days ago):

  • Leg/left weakness and gives out
    Degenerative disc disease
    L1 S5 herniation/bulging
    Numbness tingling loss of use and feeling left leg
    Severe pain

    Reply

  • From this study (3 days ago):

  • I was on a combination of Depakote ER, Birth control, and Prednisone and gained 40lbs in a matter of two months. I went from being a normal weight of 125 at 5'3" to 165 plus. The symptom that was the worst was that my size C breasts went from that to a DD and now a DDD. It is very uncomfortable and I have back problems so that does not help.
    I found info at one time that said the birth control tricks your body into thinking it is pregnant and then the Depakote ER expands your breasts in a reaction of the two meds. I need to know if one of these or two or all of these meds induced my larger breasts. Thank you!

    Reply

  • From this study (3 weeks ago):

  • Constant movement
    Jaw movement side to side and a hard bite (can hear teeth hit each other) every 20 min or so.

    Reply

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On eHealthMe, Depakote (divalproex sodium) is often used for bipolar disorder. Find out below the conditions Depakote is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Depakote used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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