Review: could Depakote cause Sleeplessness?


Sleeplessness is found among people who take Depakote, especially for people who are female, 50-59 old , have been taking the drug for 2 - 5 years, also take medication Seroquel, and have Bipolar disorder . We study 29,120 people who have side effects while taking Depakote from FDA and social media. Among them, 953 have Sleeplessness. Find out below who they are, when they have Sleeplessness and more.

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Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from Depakote 33,084 users)


Sleeplessness (a sleep disorder in which there is an inability to fall asleep or to stay asleep as long as desired) has been reported by people with breathing difficulty, suicidal ideation, thrombocytopenia, feeling abnormal, diarrhea (latest reports from 141,076 Sleeplessness patients).

On Aug, 20, 2016

29,120 people reported to have side effects when taking Depakote.
Among them, 953 people (3.27%) have Sleeplessness

Number of reports submitted per year:

Could Depakote cause Sleeplessness?

Time on Depakote when people have Sleeplessness *:

  • < 1 month: 20.0 %
  • 1 - 6 months: 12.0 %
  • 6 - 12 months: 8.0 %
  • 1 - 2 years: 9.33 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 5.33 %
  • 10+ years: 12.0 %

Gender of people who have Sleeplessness when taking Depakote *:

  • female: 61.21 %
  • male: 38.79 %

Age of people who have Sleeplessness when taking Depakote *:

  • 0-1: 0.39 %
  • 2-9: 2.33 %
  • 10-19: 7.37 %
  • 20-29: 9.31 %
  • 30-39: 17.98 %
  • 40-49: 24.45 %
  • 50-59: 24.71 %
  • 60+: 13.45 %

Severity if Sleeplessness when taking Depakote **:

  • least: 9.09 %
  • moderate: 36.36 %
  • severe: 54.55 %
  • most severe: 0.0 %

How people recovered from Sleeplessness **:

  • while on drug: 0.0 %
  • after off the drug: 25 %
  • not yet: 75 %

Top conditions involved for these people *:

  • Bipolar Disorder (267 people)
  • Depression (170 people)
  • Anxiety (96 people)
  • Insomnia (86 people)
  • Pain (79 people)

Top co-used drugs for these people *:

  • Seroquel (266 people)
  • Zyprexa (165 people)
  • Xanax (128 people)
  • Paxil (127 people)
  • Risperdal (118 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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