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Review: could Depakote cause Splenomegaly?

We study 29,591 people who have side effects while taking Depakote from FDA and social media. Among them, 56 have Splenomegaly. Find out below who they are, when they have Splenomegaly and more.

Get connected: join a mobile support group for people who take Depakote and have Splenomegaly >>>

Depakote

Depakote (latest outcomes from 30,913 users) has active ingredients of divalproex sodium. It is often used in bipolar disorder.

Splenomegaly

Splenomegaly (enlargement of spleen) (latest reports from 39,319 patients) has been reported by people with rheumatoid arthritis, hiv infection, high blood pressure, multiple sclerosis, hepatitis c.

On Aug, 27, 2014: 29,588 people reported to have side effects when taking Depakote. Among them, 56 people (0.19%) have Splenomegaly. They amount to 0.14% of all the 39,281 people who have Splenomegaly on eHealthMe.

Trend of Splenomegaly in Depakote reports

Time on Depakote when people have Splenomegaly * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Splenomegaly0.00%66.67%0.00%0.00%33.33%0.00%0.00%

Gender of people who have Splenomegaly when taking Depakote * :

FemaleMale
Splenomegaly51.67%48.33%

Age of people who have Splenomegaly when taking Depakote * :

0-12-910-1920-2930-3940-4950-5960+
Splenomegaly0.00%0.00%7.55%16.98%9.43%26.42%37.74%1.89%

Severity of Splenomegaly when taking Depakote ** :

n/a

How people recovered from Splenomegaly ** :

n/a

Top conditions involved for these people * :

  1. Hiv infection (5 people, 8.93%)
  2. Sleep disorder (5 people, 8.93%)
  3. Ill-defined disorder (3 people, 5.36%)
  4. Agitation (3 people, 5.36%)
  5. Bipolar i disorder (2 people, 3.57%)

Top co-used drugs for these people * :

  1. Ativan (20 people, 35.71%)
  2. Xanax (17 people, 30.36%)
  3. Lasix (13 people, 23.21%)
  4. Imodium (12 people, 21.43%)
  5. Zometa (12 people, 21.43%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Splenomegaly while taking Depakote?

Get connected! Join a mobile support group:
- support group for people who take Depakote and have Splenomegaly
- support group for people who take Depakote
- support group for people who have Splenomegaly

Comments from related studies:

  • From this study (6 hours ago):

  • Seated for approx 3 minutes before BP was taken. Result 90/66, pulse 65. I get dizzy and out of breath climbing 2 flights of stairs. I am a competitive Masters Level Bicyclist.

    Reply

  • From this study (7 days ago):

  • Upon reduction of jakafi dose due to low platelet count from 20 mg to 5 mg every 12 hours patient experienced extreme pain experienced low blood pressure and rapid heartbeat and with admission to emergency was treated for shock and then diagnosed with toxic shock syndrome and treated for that. The blood and urine tests however showed ant reason for infection after 5 days. He died 40 hours after reaching the hospital. Cytokine overreaction is my belief that brought on a septic shock like syndrome.

    Reply

    Ann Chris on Oct, 14, 2014:

    I agree. This took place 16 months ago and was done as directed by the drug rep. Since that time much more has been made known about dosage. The patient was also started on the high dose where research shows now the dose should be started low and slowly worked up. My theory is the rapid decrease in the drug caused a cytokine reaction causing system shock.

    Reply

    Dave M. on Oct, 12, 2014:

    Maybe patient should not have been on 20mg. Something else likely going on here with sudden reduction from 20mg to 5mg. Sudden reduction due to sudden drop in platelets. Slower dose reduction with transfusion if required would be in order.

    Reply

  • From this study (3 weeks ago):

  • Got the paranoia after I started meds

    Reply

Post a new comment    OR    Read more comments

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More reviews for: Depakote, Splenomegaly

On eHealthMe, Depakote (divalproex sodium) is often used for bipolar disorder. Find out below the conditions Depakote is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Depakote used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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