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Review: could Depo-medrol cause Weight gain?

Summary: Weight gain could be caused by Depo-medrol, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take Neurontin, and have Pain.

We study 2,137 people who have side effects while taking Depo-medrol from FDA and social media. Among them, 114 have Weight gain. Find out below who they are, when they have Weight gain and more.

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Depo-medrol (latest outcomes from 2,177 users) has active ingredients of methylprednisolone acetate. Commonly reported side effects of Depo-medrol include pain, pain exacerbated, stress and anxiety, headache, nausea.

Weight gain

Weight gain (latest reports from 521,504 patients) has been reported by people with depression, high blood pressure, bipolar disorder, pain, high blood cholesterol.

On Apr, 11, 2014: 2,137 people reported to have side effects when taking Depo-medrol. Among them, 114 people (5.33%) have Weight Gain. They amount to 0.02% of all the 520,710 people who have Weight Gain on eHealthMe.

Trend of Weight gain in Depo-medrol reports

Time on Depo-medrol when people have Weight gain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight gain60.00%24.00%8.00%8.00%0.00%0.00%0.00%

Gender of people who have Weight gain when taking Depo-medrol * :

Weight gain84.44%15.56%

Age of people who have Weight gain when taking Depo-medrol * :

Weight gain0.00%1.75%0.88%0.88%7.89%20.18%39.47%28.95%

Severity of Weight gain when taking Depo-medrol ** :


How people recovered from Weight gain ** :


Top conditions involved for these people * :

  1. Pain (31 people, 27.19%)
  2. Back pain (24 people, 21.05%)
  3. Neck pain (18 people, 15.79%)
  4. Muscle spasms (13 people, 11.40%)
  5. Sciatica (12 people, 10.53%)

Top co-used drugs for these people * :

  1. Neurontin (37 people, 32.46%)
  2. Protonix (36 people, 31.58%)
  3. Aredia (31 people, 27.19%)
  4. Zometa (31 people, 27.19%)
  5. Zantac (30 people, 26.32%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Depo-medrol, Weight gain

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Comments from related studies:

  • From this study (1 week ago):

  • I am an obese male who lost 70 pounds over the last three years. My weight remained stable for nearly one year. My doctor prescribed and I have been compliant with taking the above mentioned medications for the last nine months and they were keeping my blood glucose in check and lowered my A1C by 60% over that time. Over the last three months, I have gained 8 lbs. without any change to my caloric intake or exercise regimen (I walk two miles a day.). Has my body adapted to taking these medications and now be causing weight gain?


  • From this study (2 weeks ago):

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Depo-medrol side effects


Related symptom

- Weight Gain



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