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Review: could Depo-medrol cause Weight gain (Weight increased)?

Summary: Weight gain is found among people who take Depo-medrol, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take medication Neurontin, and have Pain.

We study 2,148 people who have side effects while taking Depo-medrol from FDA and social media. Among them, 114 have Weight gain. Find out below who they are, when they have Weight gain and more.

You are not alone: join a support group for people who take Depo-medrol and have Weight gain >>>



Depo-medrol has active ingredients of methylprednisolone acetate. It is often used in birth control. (latest outcomes from 2,183 Depo-medrol users)

Weight gain

Weight gain has been reported by people with depression, high blood pressure, bipolar disorder, pain, high blood cholesterol. (latest reports from 76,623 Weight gain patients)

On Apr, 17, 2015: 2,148 people reported to have side effects when taking Depo-medrol. Among them, 114 people (5.31%) have Weight Gain.

Trend of Weight gain in Depo-medrol reports

Time on Depo-medrol when people have Weight gain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Weight gain60.00%24.00%8.00%8.00%0.00%0.00%0.00%

Age of people who have Weight gain when taking Depo-medrol * :

Weight gain0.00%1.75%0.88%0.88%7.89%20.18%39.47%28.95%

Severity of Weight gain when taking Depo-medrol ** :


How people recovered from Weight gain ** :


Top conditions involved for these people * :

  1. Pain (31 people, 27.19%)
  2. Back pain (24 people, 21.05%)
  3. Neck pain (18 people, 15.79%)
  4. Muscle spasms (13 people, 11.40%)
  5. Sciatica (12 people, 10.53%)

Top co-used drugs for these people * :

  1. Neurontin (37 people, 32.46%)
  2. Protonix (36 people, 31.58%)
  3. Aredia (31 people, 27.19%)
  4. Zometa (31 people, 27.19%)
  5. Zantac (30 people, 26.32%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of depo-medrol and weight gain on

Do you have Weight Gain while taking Depo-medrol?




You are not alone! Join a support group on :
- support group for people who take Depo-medrol and have Weight Gain
- support group for people who take Depo-medrol
- support group for people who have Weight Gain

Drugs in real world that are associated with:

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Recent Depo-medrol related drug comparison:

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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