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Review: could Depo-provera cause Depression?

Summary: Depression is found among people who take Depo-provera, especially for people who are female, 20-29 old, have been taking the drug for < 1 month, also take medication Accutane, and have Birth control.

We study 9,948 people who have side effects while taking Depo-provera from FDA and social media. Among them, 715 have Depression. Find out below who they are, when they have Depression and more.

You are not alone: join a mobile support group for people who take Depo-provera and have Depression >>>






Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. (latest outcomes from 10,364 Depo-provera users)


Depression has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, high blood pressure. (latest reports from 276,944 Depression patients)

On Jan, 19, 2015: 9,948 people reported to have side effects when taking Depo-provera. Among them, 715 people (7.19%) have Depression.

Trend of Depression in Depo-provera reports

Time on Depo-provera when people have Depression * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Age of people who have Depression when taking Depo-provera * :


Severity of Depression when taking Depo-provera ** :

leastmoderateseveremost severe

How people recovered from Depression ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Contraception (232 people, 32.45%)
  2. Endometriosis (36 people, 5.03%)
  3. Depression (33 people, 4.62%)
  4. Blood cholesterol increased (21 people, 2.94%)
  5. Asthma (20 people, 2.80%)

Top co-used drugs for these people * :

  1. Accutane (45 people, 6.29%)
  2. Lexapro (35 people, 4.90%)
  3. Effexor (35 people, 4.90%)
  4. Paxil (30 people, 4.20%)
  5. Seroquel (27 people, 3.78%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Depression while taking Depo-provera?

You are not alone! Join a mobile support group:
- support group for people who take Depo-provera and have Depression
- support group for people who take Depo-provera
- support group for people who have Depression

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More questions for: Depo-provera, Depression

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More reviews for: Depo-provera, Depression

Comments from related studies:

  • From this study (2 years ago):

  • Carmen on May, 4, 2012:

    My experience with Depo has been a nightmare/horror story that seems to never end. I physically look and feel different compared to before my shot. First let me say that I took this shot a few times when I was about 17/18 years old. Didn't 'think' I had any side effects back then.... Had the shot for the first time since then back in September of 2010....NEVER AGAIN! Let me add to the past by saying now with all of the side effects I began experiencing within 2 weeks of that September 2010 shot, I now realize I DID have side effects when I was younger, I just didn't realize it then. My whole life my vision was 20/20 until I was about 18/19/20. My eyes began bothering me, felt blurry all the time, was having alot of headaches. Found out I suddenly had a stigmatism that I never had before. I've had circulation problems all through my 20's. So fast forward....2 weeks after my shot in September of 2010, I began experiencing horrifying hair changes and I began bleeding. It was 'that time of the month' after that every single day through January of 2011. Yes, 4-5 months of bleeding every day!


    Carmen on May, 4, 2012:

    (The rest of my comment continued from above) My hair? My hair became extremely extremely disgustingly greasy and slowly became thinner and thinner. Before that, my hair was beautiful, thick, naturally curly/wavy. The kind of hair that I could wear curly or straighten with a flat iron. Once I finally realized the cause, I didnt' go back for my second shot! I realized when researching my hair issues....I was HORRIFIED! Also at that time...I had lost all of my pregnancy weight from giving birth to twins just 7 months before this. That August I was teeny tiny. I ate right and exercised all of that pregnancy weight off. My whole life I never ever had problems with my weight. After a baby I would lose the weight if I ate right and exercised. Well, within the first 6 months of depo for me, I gained 10-20 pounds. Ok, so I tried to stop my hair problems. I'm still fighting these problems almost 2 years after that shot. I have some other health issues that I wonder if it could be related to the shots when I was younger. Heart issues, breathing issues, back issues. The back issues just started this past year. Where it's hard for me to sit up straight. Fast forward to now. I've managed to control my hair even though it will never be the same again. I use organic shampoos only, preferably anything with Green Tea. It helps a lot if you have this problem with oily hair which I NEVER had until 2 weeks after that shot in September! My hair texture has also changed like someone else commented. My hair seems stringy and dry now, along with a little bit oily inspite of the organic shampoo that thankfully helps because it could be so much worse! At one point I avoided conditioner for almost a year!


    Carmen on May, 4, 2012:

    (sorry, there was more to my comment....continued from above...this is it though :) Before this experience my hair was the opposite, I would struggle to tame my mane because it was so thick, etc. As for my weight, I am disgusted. No matter how hard I try, I can't seem to lose this 10-15 pounds. I lost 5 or so but can't get the rest off. I want to vomit when I look at myself. I'm also severely bloated ALLL day no matter how much or little I eat! It seems like I gain weight just from breathing! Mood problems. I already have mood issues, so this shot made them worse. That is pretty much under control now though. Within the past year, I also started having problems with my legs, bad circulation problems through my whole body with veins. Even my arms. But my legs also had bad edema at one point. I take Horsechestnut and it helps my circulation a lot. If I miss a pill my legs ache. My legs were in a lot of pain. My knees started bothering me a lot too, I can feel what my mother says sounds like 'calcium deposits'....a strange noise my knees make. Like a popping noise? when I move them a certain way. Not all the time. I started taking Tums as a calcium supplement recently too. Another thing I do with my hair is I take a prenatal helps with the hair loss problem!!! Helped a lot actually. I feel like I look really old and terrible lately. This didn't start until after the depo. Hopefully I will be able to get back to the old weight and hair make me want to cry sometimes because I'm trying and trying but my hair is just not the same. My belly looks like I'm 3 months pregnant sometimes from the bloating. Doesn't make you feel so pretty.... :(


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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