Review: could Depo-provera cause Fibromyalgia?


Fibromyalgia is found among people who take Depo-Provera, especially for people who are female, 40-49 old , have been taking the drug for < 1 month, also take medication Albuterol, and have Contraception . We study 9,769 people who have side effects while taking Depo-provera from FDA and social media. Among them, 43 have Fibromyalgia. Find out below who they are, when they have Fibromyalgia and more.

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Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. (latest outcomes from Depo-provera 10,933 users)


Fibromyalgia (a long-term condition which causes pain all over the body) has been reported by people with pain, drug ineffective, drowsiness, insomnia, fatigue (latest reports from 29,604 Fibromyalgia patients).

On Aug, 18, 2016

9,769 people reported to have side effects when taking Depo-provera.
Among them, 43 people (0.44%) have Fibromyalgia

Number of reports submitted per year:

Could Depo-provera cause Fibromyalgia?

Time on Depo-provera when people have Fibromyalgia *:

  • < 1 month: 47.83 %
  • 1 - 6 months: 4.35 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 13.04 %
  • 2 - 5 years: 21.74 %
  • 5 - 10 years: 8.7 %
  • 10+ years: 4.35 %

Gender of people who have Fibromyalgia when taking Depo-provera *:

  • female: 97.5 %
  • male: 2.5 %

Age of people who have Fibromyalgia when taking Depo-provera *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 8 %
  • 20-29: 32 %
  • 30-39: 24 %
  • 40-49: 32 %
  • 50-59: 0.0 %
  • 60+: 4 %

Severity if Fibromyalgia when taking Depo-provera **:

  • least: 0.0 %
  • moderate: 0.0 %
  • severe: 100 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Contraception (12 people)
  • Endometriosis (7 people)
  • Pain (5 people)
  • Restless Legs Syndrome (3 people)
  • Palpitations (3 people)

Top co-used drugs for these people *:

  • Lexapro (7 people)
  • Albuterol (7 people)
  • Singulair (6 people)
  • Advair Diskus 100/50 (5 people)
  • Atenolol (4 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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