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Review: could Dexamethasone cause Perineal pain (Groin pain)?

Summary: Perineal pain is found among people who take Dexamethasone, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Zometa, and have Testis cancer.

We study 53,184 people who have side effects while taking Dexamethasone from FDA and social media. Among them, 78 have Perineal pain. Find out below who they are, when they have Perineal pain and more.

You are not alone: join a mobile support group for people who take Dexamethasone and have Perineal pain >>>






Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. (latest outcomes from 53,458 Dexamethasone users)

Perineal pain

Perineal pain has been reported by people with osteoporosis, birth control, osteopenia, pain, rheumatoid arthritis. (latest reports from 4,457 Perineal pain patients)

On Jan, 1, 2015: 53,178 people reported to have side effects when taking Dexamethasone. Among them, 78 people (0.15%) have Perineal Pain.

Trend of Perineal pain in Dexamethasone reports

Time on Dexamethasone when people have Perineal pain * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Perineal pain66.67%33.33%0.00%0.00%0.00%0.00%0.00%

Gender of people who have Perineal pain when taking Dexamethasone * :

Perineal pain33.73%66.27%

Age of people who have Perineal pain when taking Dexamethasone * :

Perineal pain0.00%1.49%1.49%25.37%20.90%2.99%2.99%44.78%

Severity of Perineal pain when taking Dexamethasone ** :


How people recovered from Perineal pain ** :


Top conditions involved for these people * :

  1. Testis cancer (30 people, 38.46%)
  2. Muscle spasms (14 people, 17.95%)
  3. Multiple myeloma (14 people, 17.95%)
  4. Pain (14 people, 17.95%)
  5. Metastases to bone (11 people, 14.10%)

Top co-used drugs for these people * :

  1. Zometa (34 people, 43.59%)
  2. Aranesp (31 people, 39.74%)
  3. Cisplatin (31 people, 39.74%)
  4. Protonix (31 people, 39.74%)
  5. Etoposide (29 people, 37.18%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Perineal Pain while taking Dexamethasone?

You are not alone! Join a mobile support group:
- support group for people who take Dexamethasone and have Perineal Pain
- support group for people who take Dexamethasone
- support group for people who have Perineal Pain

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More questions for: Dexamethasone, Perineal pain

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Comments from related studies:

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  • Many other drugs during Velcade weeks


  • From this study (3 months ago):

  • twice only


  • From this study (3 months ago):

  • All of this started after I finished masturbating one night two years ago. Upon climax, I was struck with an instant, excruciating pain in my rectum and scrotum areas. My penis immediately went numb and it felt as though every muscle in my perineum was seized up. I had no control, they would not unlock at all. Later on, my whole body began to go numb, except for my insides which felt like they were full of broken glass.

    Beforehand, I did have slight symptoms like these, but nothing even a tiny fraction as severe. Once in a while I would have a fullness sensation in my rectum or my abdominal muscles would lock up.

    I have tried anal stimulation in the past if that is of any help. I also may have an internal rectal prolapse(may or may not be related to the stimulation).

    When I have a flare-up, which is frequent, I'm unable to function on any level and am bedridden. Walking sends bolts of pain from my penis, through my buttocks, and down my legs.

    Every sensation except for the pain and the internal hypersensitivity is muted. My skin will be very cold and I barely register any touch. Except for my pelvic area, where I cannot tolerate being touched or examined. It is simply too sensitive and everything is painful.

    My vision seems to dim during flare-ups, and there is a constant thrumming noise in my ears that impairs my hearing. At the same time, I'm also hypersensitive to noise.

    I'm unable to tolerate any temperature below 80 degrees. My body does not seem to produce enough heat. Before this happened, I worked in a cold environment without trouble. Any cold air feels like acid on my skin. It is extremely unpleasant.

    No doctor has been able to give me a true diagnosis despite endless testing, including an EEG, EMG, multiple MRIs, and a CT scan.

    These symptoms make no sense to me, nor can any doctor I've seen give me a diagnosis. Some of it seems like a disease, and some of it seems like an injury. I just want some relief. If I have to be gutted like a fish to fix it, so be it.


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