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Review: could Doxycycline cause Suicide attempt?

Summary: Suicide attempt is found among people who take Doxycycline, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take medication Accutane, and have Acne.

We study 12,094 people who have side effects while taking Doxycycline from FDA and social media. Among them, 116 have Suicide attempt. Find out below who they are, when they have Suicide attempt and more.

You are not alone: join a support group for people who take Doxycycline and have Suicide attempt >>>



Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. (latest outcomes from 13,709 Doxycycline users)

Suicide attempt

Suicide attempt has been reported by people with depression, quit smoking, stress and anxiety, pain, bipolar disorder. (latest reports from 32,157 Suicide attempt patients)

On Apr, 1, 2015: 12,090 people reported to have side effects when taking Doxycycline. Among them, 116 people (0.96%) have Suicide Attempt.

Trend of Suicide attempt in Doxycycline reports

Time on Doxycycline when people have Suicide attempt * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Suicide attempt42.31%3.85%0.00%0.00%46.15%7.69%0.00%

Gender of people who have Suicide attempt when taking Doxycycline * :

Suicide attempt59.02%40.98%

Age of people who have Suicide attempt when taking Doxycycline * :

Suicide attempt0.00%0.00%12.00%29.00%20.00%29.00%4.00%6.00%

Severity of Suicide attempt when taking Doxycycline ** :

leastmoderateseveremost severe
Suicide attempt0.00%50.00%0.00%50.00%

How people recovered from Suicide attempt ** :

while on the drugafter off the drugnot yet
Suicide attempt0.00%0.00%100.00%

Top conditions involved for these people * :

  1. Acne (23 people, 19.83%)
  2. Depression (23 people, 19.83%)
  3. Smoking cessation therapy (21 people, 18.10%)
  4. Anxiety (14 people, 12.07%)
  5. Insomnia (12 people, 10.34%)

Top co-used drugs for these people * :

  1. Accutane (24 people, 20.69%)
  2. Chantix (20 people, 17.24%)
  3. Trimethoprim + sulfamethoxazole (19 people, 16.38%)
  4. Zyprexa (17 people, 14.66%)
  5. Doxycycline hyclate (17 people, 14.66%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

Comments for this study:

Mr. Davis (2 years ago):

I'm a 42 year old Male father of two recently divorced. I started taking Doryx pills for a ruptured cyst several months ago and it did reduce the size and swelling. I have never thought about suicide before but within a few weeks of starting this medicine I have had the idea just pop into my head. Not sure why, i'm healthy and well off and have a great relationship with my children and friends. I stopped taking the medicine for several months and have not had any "thoughts" since.
Recently I began taking it again after checking the side effects and not finding depression or suicidal tendencies among them. After a couple days back on, I again started having these thoughts. This prompted me to query doryx + suicide on google and found this page and a few others that mention others having similar experiences. I am actively keeping myself from thinking this way by staying busy and trying to enjoy life more. Maybe a larger study on this should be conducted by the FDA and if even less than 1% have the same side effects it should be noted as a possible side effect.
I have told a few people that are close to me and their answer was to STOP taking it. Currently I feel the benefit outweighs the risks since I can't imagine myself actually commiting suicide or even trying it. Just wanted to share this and hopefully it helps someone else know they are not alone and may need to keep their brain from being idle and drifting to thoughts like this.
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Carrie (3 years ago):

My 14 y/o daughter just attempted suicide after 7 months on doxycycline for acne. She now says she's had suicidal ideation since shortly after starting the medication 7 months ago. Her dose of doxycycline was doubled a couple of weeks before her suicide attempt.

She herself says she is not sad, shows no other signs of depression and does not understand why she felt compelled to kill herself. She gets good grades, is involved with clubs and friends, and demonstrates appropriate affection. The timing with the doxycycline is just too coincidental to not be connected.
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