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Review: could Enbrel cause Gastrointestinal disorder?

Summary: Gastrointestinal disorder could be caused by Enbrel, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Methotrexate, and have Rheumatoid arthritis.

We study 174,894 people who have side effects while taking Enbrel from FDA and social media. Among them, 235 have Gastrointestinal disorder. Find out below who they are, when they have Gastrointestinal disorder and more.

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Enbrel (latest outcomes from 175,451 users) has active ingredients of etanercept. It is often used in rheumatoid arthritis.

Gastrointestinal disorder

Gastrointestinal disorder (functional problems of gastrointestinal tract) (latest reports from 104,930 patients) has been reported by people with acne, osteoporosis, high blood pressure, multiple sclerosis, depression.

On Apr, 20, 2014: 174,892 people reported to have side effects when taking Enbrel. Among them, 235 people (0.13%) have Gastrointestinal Disorder. They amount to 0.22% of all the 104,906 people who have Gastrointestinal Disorder on eHealthMe.

Trend of Gastrointestinal disorder in Enbrel reports

Time on Enbrel when people have Gastrointestinal disorder * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Gastrointestinal disorder6.56%26.23%16.39%16.39%21.31%9.84%3.28%

Gender of people who have Gastrointestinal disorder when taking Enbrel * :

Gastrointestinal disorder75.92%24.08%

Age of people who have Gastrointestinal disorder when taking Enbrel * :

Gastrointestinal disorder0.00%0.00%0.54%1.62%9.19%8.65%30.81%49.19%

Severity of Gastrointestinal disorder when taking Enbrel ** :


How people recovered from Gastrointestinal disorder ** :


Top conditions involved for these people * :

  1. Rheumatoid arthritis (106 people, 45.11%)
  2. Ankylosing spondylitis (23 people, 9.79%)
  3. Psoriasis (15 people, 6.38%)
  4. Psoriatic arthropathy (11 people, 4.68%)
  5. Hypertension (7 people, 2.98%)

Top co-used drugs for these people * :

  1. Methotrexate (67 people, 28.51%)
  2. Prednisone (47 people, 20.00%)
  3. Folic acid (21 people, 8.94%)
  4. Humira (18 people, 7.66%)
  5. Alendronate sodium (12 people, 5.11%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Enbrel, Gastrointestinal disorder

You can also:

On eHealthMe, Enbrel (etanercept) is often used for rheumatoid arthritis. Find out below the conditions Enbrel is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Enbrel used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (7 days ago):

  • Trying to determine if the timing of these drugs- especially the weekly mtx- should be staggered during the day to ensure they are appropriately absorbed. Periodic seizures continue- about once a quarter.


  • From this study (1 month ago):

  • I have been on the nexplanon for just short of a year and now for 5 weeks have been taking enbrel for my ankylosing spondylitis and i have gained 20+ lbs by breasts hurt badly and now out of no where i am spotting and i havent had a period since last july. I would like to know why these symptoms are so severe


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Related study

- Enbrel side effects


Related symptom

- Gastrointestinal Disorder



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