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Review: could Enbrel cause Kidney failure (Acute kidney failure)?

Summary: Kidney failure is found among people who take Enbrel, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Methotrexate, and have Rheumatoid arthritis.

We study 174,971 people who have side effects while taking Enbrel from FDA and social media. Among them, 507 have Kidney failure. Find out below who they are, when they have Kidney failure and more.

You are not alone: join a mobile support group for people who take Enbrel and have Kidney failure >>>

 

 

 

 

Enbrel

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. (latest outcomes from 175,534 Enbrel users)

Kidney failure

Kidney failure (loss of kidney function) has been reported by people with high blood pressure, coronary artery bypass, diabetes, multiple myeloma, pain. (latest reports from 57,656 Kidney failure patients)

On Jan, 26, 2015: 174,971 people reported to have side effects when taking Enbrel. Among them, 507 people (0.29%) have Kidney Failure.

Trend of Kidney failure in Enbrel reports

Time on Enbrel when people have Kidney failure * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Kidney failure17.17%23.61%14.59%12.45%21.03%9.01%2.15%

Gender of people who have Kidney failure when taking Enbrel * :

FemaleMale
Kidney failure62.15%37.85%

Age of people who have Kidney failure when taking Enbrel * :

0-12-910-1920-2930-3940-4950-5960+
Kidney failure0.00%1.75%0.58%1.17%1.17%15.79%30.70%48.83%

Severity of Kidney failure when taking Enbrel ** :

leastmoderateseveremost severe
Kidney failure0.00%0.00%100.00%0.00%

How people recovered from Kidney failure ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (311 people, 61.34%)
  2. Psoriasis (80 people, 15.78%)
  3. Psoriatic arthropathy (45 people, 8.88%)
  4. Osteoporosis (34 people, 6.71%)
  5. Systemic lupus erythematosus (28 people, 5.52%)

Top co-used drugs for these people * :

  1. Methotrexate (112 people, 22.09%)
  2. Prednisone (71 people, 14.00%)
  3. Lasix (53 people, 10.45%)
  4. Plaquenil (39 people, 7.69%)
  5. Aspirin (38 people, 7.50%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Kidney Failure while taking Enbrel?

You are not alone! Join a mobile support group:
- support group for people who take Enbrel and have Kidney Failure
- support group for people who take Enbrel
- support group for people who have Kidney Failure

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More questions for: Enbrel, Kidney failure

You may be interested at these reviews (Write a review):

  • Hair loss with enbrel
    I have been on Enbrel for 4 months and started seeing significant hair thinning at the second month of treatments (50 mg once per week). My Rhuematologist suggested 800 mcg of folic acid. I am still losing hair although I am feeling so much better.
  • Etanercept and irritability
    I have been on Etanercept for 8 years for Psoriasis. Previous to this I was on
    Methotrexate, Cyclosporine, Retinodes and ACTH injections.Since being on 25mg twice a week I have been 98% clear.The only side effect to date is "Irritability" which lasts about 24hrs.
    This Drug has been my saving grace.
  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • My ex-boyfriend's effexor effects (1 response)
    In my fifth year of living with my ex-boyfriend, he began taking Effexor and soon developed urinary incontinence, kidney failure and nightmares or night terrors so severe that he frequently screamed for prolonged periods, flailed and threw punches in his sleep. Upon ceasing to take Effexor, his sleep returned to normal. His kidneys also recovered, and he regained the ability to control urination. About a year after that, he was arrested for downloading child pornography, and I haven't spoken to him since. I'm not suggesting that Effexor caused him to become a pedophile, but it has been noted to produce personality changes in some users. It would be hard to ascertain whether any or all of these side effects resulted from the drug, but I would NEVER take it or allow anyone I cared about to do so. He had never exhibited any such symptoms before taking it, and I feel it ruined his life on many levels.
  • Vasculitis from enbrel
    I have deep scars on my legs from vasculitis. This was caused by Enbrel. Initially no one would connect the two: per my rheumatologist 'no one has ever reported vasculitis as a side effect of enbrel.' (2003)

    I had to suspend the enbrel for 8 weeks in preparation for complex abdominal surgery. The vasculitis started to heal. Several weeks after the surgery I resumed enbrel and the vasculitis returned by the second or third enbrel shot. The Dr was reluctantly willing to concede that 'it may have been the enbrel.'

    The vasculitis was horrific. I've never felt so much pain, pain that wasn't abated in the least by pain medicine. My dermatologist describe it as being equivalent to a third degree burn: the skin dies, nerves start to regenerate but aren't protected by the dermis.

    The scars look like I had flesh torn from my legs that didn't quite 'fill in.'

    Rheumatologists are too pushy about these biological medicines. They brush past even the most serious side effects. Anything for mobility... I'd prefer not to skip to dialysis sessions or treatment for other organ failure!

More reviews for: Enbrel, Kidney failure

Comments from related studies:

  • From this study (2 weeks ago):

  • Spotty abdominal pain, loss of appetitie, general tightness in tummy, fatigue, and nasuea.

    Reply

  • From this study (2 weeks ago):

  • I had my hip replaced in July. I had an EKG where they discovered I have afib. I was prescribed metoprolol for that. And i noticed that I've been getting sores and lesions on my legs and arms. I also have been getting hot flashes in the mornindgand have had some large bruising from what would seem like a minor impact.

    Reply

  • From this study (1 month ago):

  • I have had insomnia off and on all my life until I turned 40 and the I was diagnosed with Psoriatic Arthritis and I was tired all the time and I was sleeping a lot for me and it was good to be able to sleep. The doctor put me on Methotrexate and Enbrel and I could still sleep not as much as before I started the drugs but better than before when I was younger. I went on and off the Enbrel and Methotrexate over the years. I took Adipex for about six months this year for weight loss and that is when I started taking Benadryl to sleep, after I stopped the Adipex and started the Enbrel again my insomnia is worse, I take 2 Benadryl and a 0.5 Xanax every night to sleep and most nights I still don't get to sleep before 1am and many nights even later, I get up at 7am everyday no mater what time I get to sleep and most of the time I am not tired when I wake up, it just really bothers me not being able to sleep when everyone else does.

    Reply

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