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Review: could Enbrel cause Multiple sclerosis?





Summary: Multiple sclerosis is found among people who take Enbrel, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take medication Methotrexate, and have Rheumatoid arthritis.

We study 174,963 people who have side effects while taking Enbrel from FDA and social media. Among them, 471 have Multiple sclerosis. Find out below who they are, when they have Multiple sclerosis and more.

You are not alone: join a mobile support group for people who take Enbrel and have Multiple sclerosis >>>

Enbrel

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. (latest outcomes from Enbrel 175,525 users)

Multiple sclerosis

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) has been reported by people with relapsing-remitting multiple sclerosis, depression, pain, high blood pressure, rheumatoid arthritis.(latest reports from Multiple sclerosis 223,215 patients)

On Dec, 14, 2014: 174,963 people reported to have side effects when taking Enbrel. Among them, 471 people (0.27%) have Multiple Sclerosis.

Trend of Multiple sclerosis in Enbrel reports

Time on Enbrel when people have Multiple sclerosis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Multiple sclerosis4.27%17.54%16.59%18.96%33.65%7.58%1.42%

Gender of people who have Multiple sclerosis when taking Enbrel * :

FemaleMale
Multiple sclerosis72.77%27.23%

Age of people who have Multiple sclerosis when taking Enbrel * :

0-12-910-1920-2930-3940-4950-5960+
Multiple sclerosis0.00%0.00%1.79%4.64%22.86%40.71%24.29%5.71%

Severity of Multiple sclerosis when taking Enbrel ** :

n/a

How people recovered from Multiple sclerosis ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (127 people, 26.96%)
  2. Psoriasis (80 people, 16.99%)
  3. Psoriatic arthropathy (75 people, 15.92%)
  4. Ankylosing spondylitis (39 people, 8.28%)
  5. Pain (14 people, 2.97%)

Top co-used drugs for these people * :

  1. Methotrexate (97 people, 20.59%)
  2. Prednisone (51 people, 10.83%)
  3. Folic acid (43 people, 9.13%)
  4. Humira (29 people, 6.16%)
  5. Piroxicam (19 people, 4.03%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you have Multiple Sclerosis while taking Enbrel?

You are not alone! Join a mobile support group:
- support group for people who take Enbrel and have Multiple Sclerosis
- support group for people who take Enbrel
- support group for people who have Multiple Sclerosis

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More questions for: Enbrel, Multiple sclerosis

You may be interested at these reviews (Write a review):

  • Hair loss with enbrel
    (Posted by a 58 year old woman who has Hair Loss, Psoriatic Arthritis, and takes Enbrel)
    I have been on Enbrel for 4 months and started seeing significant hair thinning at the second month of treatments (50 mg once per week). My Rhuematologist suggested 800 mcg of folic acid. I am still losing hair although I am feeling so much better.
  • Etanercept and irritability
    (Posted by a 73 year old man who has Irritability, Psoriasis, Psoriatic Arthropathy For 55years., and takes Enbrel)
    I have been on Etanercept for 8 years for Psoriasis. Previous to this I was on
    Methotrexate, Cyclosporine, Retinodes and ACTH injections.Since being on 25mg twice a week I have been 98% clear.The only side effect to date is "Irritability" which lasts about 24hrs.
    This Drug has been my saving grace.
  • Humira: my experience
    (Posted by a 66 year old man who has Ankylosing Spondylitis, Reiter's Syndrome, Psoriatic Arthritis, and takes Methotrexate Preservative Free, Enbrel, Humira)
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Ms relapse - changed to copaxone in april
    (Posted by a 47 year old woman who has MS, and takes Copaxone)
    I've never joined one of these sites but saw this site. I have had MS for 14yrs but changed to Copaxone in April, had a relapse last week and wondered how others were getting on with it. I have a puffy left calf/ankle which can be a side effect of Copaxone - have others had this - can you reduce the swelling?
    If I haven't started using this site - my apologies!
  • Vasculitis from enbrel
    (Posted by a 53 year old woman who has Rheumatoid Arthritis, and takes Enbrel)
    I have deep scars on my legs from vasculitis. This was caused by Enbrel. Initially no one would connect the two: per my rheumatologist 'no one has ever reported vasculitis as a side effect of enbrel.' (2003)

    I had to suspend the enbrel for 8 weeks in preparation for complex abdominal surgery. The vasculitis started to heal. Several weeks after the surgery I resumed enbrel and the vasculitis returned by the second or third enbrel shot. The Dr was reluctantly willing to concede that 'it may have been the enbrel.'

    The vasculitis was horrific. I've never felt so much pain, pain that wasn't abated in the least by pain medicine. My dermatologist describe it as being equivalent to a third degree burn: the skin dies, nerves start to regenerate but aren't protected by the dermis.

    The scars look like I had flesh torn from my legs that didn't quite 'fill in.'

    Rheumatologists are too pushy about these biological medicines. They brush past even the most serious side effects. Anything for mobility... I'd prefer not to skip to dialysis sessions or treatment for other organ failure!

More reviews for: Enbrel, Multiple sclerosis

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