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Review: could Enbrel cause Stevens-johnson syndrome?

Summary: Stevens-johnson syndrome could be caused by Enbrel, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Methotrexate, and have Rheumatoid arthritis.

We study 174,892 people who have side effects while taking Enbrel from FDA and social media. Among them, 142 have Stevens-johnson syndrome. Find out below who they are, when they have Stevens-johnson syndrome and more.

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Enbrel

Enbrel (latest outcomes from 175,451 users) has active ingredients of etanercept. It is often used in rheumatoid arthritis.

Stevens-johnson syndrome

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe) (latest reports from 134,807 patients) has been reported by people with convulsion, high blood pressure, epilepsy, ill-defined disorder, fever.

On Apr, 16, 2014: 174,892 people reported to have side effects when taking Enbrel. Among them, 142 people (0.08%) have Stevens Johnson Syndrome. They amount to 0.11% of all the 134,794 people who have Stevens Johnson Syndrome on eHealthMe.

Trend of Stevens johnson syndrome in Enbrel reports

Time on Enbrel when people have Stevens johnson syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Stevens johnson syndrome41.12%32.71%1.87%7.48%14.02%0.93%1.87%

Gender of people who have Stevens johnson syndrome when taking Enbrel * :

FemaleMale
Stevens johnson syndrome74.84%25.16%

Age of people who have Stevens johnson syndrome when taking Enbrel * :

0-12-910-1920-2930-3940-4950-5960+
Stevens johnson syndrome0.00%0.00%14.02%8.41%10.28%14.02%24.30%28.97%

Severity of Stevens johnson syndrome when taking Enbrel ** :

n/a

How people recovered from Stevens johnson syndrome ** :

n/a

Top conditions involved for these people * :

  1. Rheumatoid arthritis (77 people, 54.23%)
  2. Still's disease adult onset (18 people, 12.68%)
  3. Psoriatic arthropathy (16 people, 11.27%)
  4. Arthritis (14 people, 9.86%)
  5. Psoriasis (13 people, 9.15%)

Top co-used drugs for these people * :

  1. Methotrexate (49 people, 34.51%)
  2. Prednisolone (31 people, 21.83%)
  3. Isoniazid (27 people, 19.01%)
  4. Folic acid (20 people, 14.08%)
  5. Sol-melcort (18 people, 12.68%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Enbrel, Stevens-johnson syndrome

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On eHealthMe, Enbrel (etanercept) is often used for rheumatoid arthritis. Find out below the conditions Enbrel is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Enbrel used for and how effective is it:

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Comments from related studies:

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  • Trying to determine if the timing of these drugs- especially the weekly mtx- should be staggered during the day to ensure they are appropriately absorbed. Periodic seizures continue- about once a quarter.

    Reply

  • From this study (4 weeks ago):

  • I'm currently 19 years old, and I've been on generic Zoloft 50 mg (AKA sertraline) since I was 13 due to anxiety attacks after the death of my sister. At first it didn't help much, but I kept with it to see if it would eventually help me. I started having bad anxiety again at 15 and was bumped up to 150 mg. After about a month the raised amount I was prescribed made me feel like I was going crazy. I couldn't think straight, sleep right, I was having problems with school work, and I was constantly fighting with my family, so I tapered myself back down to 100, and then back down to 50. In the last year I've had no panic attacks, but recently my anxiety has returned and I feel like it's worsening again. I can't even drink coffee without my heart pounding, causing me to feel anxious. Even getting too little sleep makes me feel anxious. I can be at work and feel anxious for no reason. I can be at work and blink and feel like I'm dreaming, and I'll get anxious for no reason at all. I grind my teeth in my sleep now, I have trouble falling asleep, trouble waking up. I just wanted to get off Zoloft, so now I'm down to a fourth of a pill every two days, but I want to be off of it for good and I honestly can't get past not taking it for a third day because my withdrawals are so severe. The electro jolt feeling makes it literally impossible to focus on anything or stand for a long period of time. Two days ago I had hives from what I thought was an allergic reaction, but the next day I went to the doctor because the itching was so severe and still there, and the urgent care facility diagnosed me with erythema multiforme minor, gave no tests, and prescribed me prednisone and a corticosteroid ointment to use and told me to have a nice day. I'm just wondering if the sertraline is causing it or if I'm actually sick with something else.

    Reply

  • From this study (1 month ago):

  • I have been on the nexplanon for just short of a year and now for 5 weeks have been taking enbrel for my ankylosing spondylitis and i have gained 20+ lbs by breasts hurt badly and now out of no where i am spotting and i havent had a period since last july. I would like to know why these symptoms are so severe

    Reply

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