Review: could Estradiol cause Spotting?


Spotting is reported only by a few people who take Estradiol. We study 5,232 people who have side effects while taking Estradiol from FDA and social media. Among them, 3 have Spotting. Find out below who they are, when they have Spotting and more.

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Estradiol has active ingredients of estradiol. It is often used in hormone replacement therapy. (latest outcomes from Estradiol 5,450 users)


Spotting (bleed during pregnancy) has been reported by people with device expulsion, heavy or prolong menstrual bleeding, vulvovaginal pruritus, heart palpitations, hypoxia (latest reports from 15,587 Spotting patients).

On Aug, 17, 2016

5,232 people reported to have side effects when taking Estradiol.
Among them, 3 people (0.06%) have Spotting

Number of reports submitted per year:

Could Estradiol cause Spotting?

Time on Estradiol when people have Spotting *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 50 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Spotting when taking Estradiol *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Spotting when taking Estradiol *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Severity if Spotting when taking Estradiol **:

  • least: 100 %
  • moderate: 0.0 %
  • severe: 0.0 %
  • most severe: 0.0 %

Top conditions involved for these people *:

  • Hormone Replacement Therapy (2 people)
  • Menopause (1 person)
  • Hot Flush (1 person)

Top co-used drugs for these people *:

  • Provera (2 people)
  • Prempro (1 person)
  • Premarin (1 person)
  • Hydrochlorothiazide (1 person)
  • Conjugated Estrogens (1 person)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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