eHealthMe - What patients like me said? eHealthMe - a cloud computing service for drugs

What patients like me said?

More tools

Review: could Flexeril cause Headache?

Summary: Headache could be caused by Flexeril, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take Neurontin, and have Pain.

We study 14,399 people who have side effects while taking Flexeril from FDA and social media. Among them, 1,293 have Headache. Find out below who they are, when they have Headache and more.

How are my drugs for patients like me? On eHealthMe, you can research 300 million drug outcomes from FDA and social media. All studies are personalized to gender and age. Start now, it's anonymous, simple & free >>>


Flexeril (latest outcomes from 16,367 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms, back pain - low. Commonly reported side effects of Flexeril include pain exacerbated, pain, stress and anxiety, anxiety aggravated, nausea aggravated.


Headache (pain in head) (latest reports from 1,205,646 patients) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis.

On Apr, 16, 2014: 14,399 people reported to have side effects when taking Flexeril. Among them, 1,293 people (8.98%) have Headache. They amount to 0.11% of all the 1,209,455 people who have Headache on eHealthMe.

Trend of Headache in Flexeril reports

Time on Flexeril when people have Headache * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Headache when taking Flexeril * :


Age of people who have Headache when taking Flexeril * :


Severity of Headache when taking Flexeril ** :

leastmoderateseveremost severe

How people recovered from Headache ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Pain (290 people, 22.43%)
  2. Depression (102 people, 7.89%)
  3. Osteoporosis (100 people, 7.73%)
  4. Hypertension (83 people, 6.42%)
  5. Muscle spasms (71 people, 5.49%)

Top co-used drugs for these people * :

  1. Neurontin (316 people, 24.44%)
  2. Oxycontin (288 people, 22.27%)
  3. Vicodin (270 people, 20.88%)
  4. Ambien (262 people, 20.26%)
  5. Xanax (240 people, 18.56%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Flexeril, Headache

You can also:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used for muscle spasms. Find out below the conditions Flexeril is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Flexeril used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

Comments from related studies:

  • From this study (1 year ago):

  • i was on clonazepam for a few years and switched to diazepam. I also was on effexor xr for several years and tapered off three months ago. I went up to 150mg bupropion for 2 weeks and went back down to 75 mg which relieved neck and headache. This was inconjunction with starting flexeril. Depression is relieved but weight gain is scary to me as i am a bulemic. I am considering increasing the wellbutrin now to 75mg to make sure depression does not return.

    Sorry this is so confusing, I exercise daily. the weight gain has me worried allot cause it just wont stop. 8 lbs in less than 6 weeks. Thank you!


    JCTwins on Oct, 27, 2012:

    I am 39 have been using Wellbutrin and generic forms
    On and off for 9 years. I you may wish to look into Wellbutrin XL it is extended release and it comes in 150 and 300 mg
    Some generics do not work for some people on ex released because the fillers are different. I pay a bit more. Even
    Dr Oz lists in his book that des prescribe this for weight Lisa at times. It did curb my emotional eating but now I think I've been in it too long. It does help with mild depression though.

    Good Luck!


  • From this study (2 years ago):

  • My Doctor's don't feel it a real problem due to medication. I'm afraid I'm getting worse not better.


  • From this study (3 years ago):

  • SO far the nuvigil makes my brain and body feel awake for the first time in a long time. No jitters or shakes or feelings of extreme energy. By 7 or 8, I am sleepy but can stay awake. The only adverse side effect is headaches, which get better when I remind myself to eat, and loss of appetite. Still waiting to see which if any adverse reactions occur with the yaz and Nuvigil, since Nuvigil reduces the effect of hormonal BC.


    emily on Oct, 1, 2011:

    Just a warning, the "adverse effects" you would see on Yaz and Nuvigil would be pregnancy. Just a heads up if that's not in your plan right now, as my doctor told me when I was on hormonal BC and Nuvigil to either always use condoms or get an IUD, since it renders hormonal BC pretty much ineffective. I opted for the Paragard IUD.


Post a new comment    OR    Read more comments

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related study

- Flexeril side effects


Related symptom

- Headache



Recent user comments

- "i have been taking Belviq for 3 months. in order to ... " (1 hour ago)

- "my chest hurts so bad from coughing i cant take the p ... " (1 hour ago)

- "I had a tooth pulled 4 days ago, the dentist prescrib ... " (2 hours ago)

- "Sarcoidosis caused complete heart block. Pacemaker im ... " (3 hours ago)

- "Why has this suddenly occurred? I have had a heart at ... " (3 hours ago)



- Check symptoms
- Check drugs
- Compare drugs
- Ask a question
- Write a review
- Report a side effect


Popular searches

- Blebitis
- Woolly Mullein
- Er Cha
- High Altitude Pulmonary Edema
- Vitreous Detachment


Drugs: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Conditions: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Side effects: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Symptoms: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

About - Terms of service - Privacy policy - Press - Advertise - Apps - Testimonials - Contact us

© 2014 All rights reserved. Use of this site constitutes acceptance of's terms of service and privacy policy.