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Review: could Flexeril cause Headache?

Summary: Headache is found among people who take Flexeril, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take medication Neurontin, and have Pain.

We study 14,476 people who have side effects while taking Flexeril from FDA and social media. Among them, 1,296 have Headache. Find out below who they are, when they have Headache and more.

You are not alone: join a mobile support group for people who take Flexeril and have Headache >>>






Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)


Headache (pain in head) has been reported by people with multiple sclerosis, depression, high blood pressure, rheumatoid arthritis, osteoporosis. (latest reports from 202,378 Headache patients)

On Feb, 26, 2015: 14,476 people reported to have side effects when taking Flexeril. Among them, 1,296 people (8.95%) have Headache.

Trend of Headache in Flexeril reports

Time on Flexeril when people have Headache * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years

Gender of people who have Headache when taking Flexeril * :


Age of people who have Headache when taking Flexeril * :


Severity of Headache when taking Flexeril ** :

leastmoderateseveremost severe

How people recovered from Headache ** :

while on the drugafter off the drugnot yet

Top conditions involved for these people * :

  1. Pain (290 people, 22.38%)
  2. Depression (102 people, 7.87%)
  3. Osteoporosis (100 people, 7.72%)
  4. Hypertension (83 people, 6.40%)
  5. Muscle spasms (72 people, 5.56%)

Top co-used drugs for these people * :

  1. Neurontin (316 people, 24.38%)
  2. Oxycontin (288 people, 22.22%)
  3. Vicodin (270 people, 20.83%)
  4. Ambien (262 people, 20.22%)
  5. Xanax (240 people, 18.52%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of flexeril and headache on

Do you have Headache while taking Flexeril?

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Comments from related studies:

  • From this study (10 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.


    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?


  • From this study (2 years ago):

  • i was on clonazepam for a few years and switched to diazepam. I also was on effexor xr for several years and tapered off three months ago. I went up to 150mg bupropion for 2 weeks and went back down to 75 mg which relieved neck and headache. This was inconjunction with starting flexeril. Depression is relieved but weight gain is scary to me as i am a bulemic. I am considering increasing the wellbutrin now to 75mg to make sure depression does not return.

    Sorry this is so confusing, I exercise daily. the weight gain has me worried allot cause it just wont stop. 8 lbs in less than 6 weeks. Thank you!


    JCTwins on Oct, 27, 2012:

    I am 39 have been using Wellbutrin and generic forms
    On and off for 9 years. I you may wish to look into Wellbutrin XL it is extended release and it comes in 150 and 300 mg
    Some generics do not work for some people on ex released because the fillers are different. I pay a bit more. Even
    Dr Oz lists in his book that des prescribe this for weight Lisa at times. It did curb my emotional eating but now I think I've been in it too long. It does help with mild depression though.

    Good Luck!


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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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