Review: could Flexeril cause Hypothyroidism?


Hypothyroidism is found among people who take Flexeril, especially for people who are female, 50-59 old , have been taking the drug for 10+ years, also take medication Synthroid, and have Pain . We study 17,048 people who have side effects while taking Flexeril from FDA and social media. Among them, 151 have Hypothyroidism. Find out below who they are, when they have Hypothyroidism and more.

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Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 19,420 users)


Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) has been reported by people with breathing difficulty, weakness, diarrhea, chest pain, fatigue (latest reports from 57,626 Hypothyroidism patients).

On Aug, 28, 2016

17,048 people reported to have side effects when taking Flexeril.
Among them, 151 people (0.89%) have Hypothyroidism

Number of reports submitted per year:

Could Flexeril cause Hypothyroidism?

Time on Flexeril when people have Hypothyroidism *:

  • < 1 month: 10 %
  • 1 - 6 months: 10 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 80 %

Gender of people who have Hypothyroidism when taking Flexeril *:

  • female: 87.92 %
  • male: 12.08 %

Age of people who have Hypothyroidism when taking Flexeril *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.67 %
  • 30-39: 2.5 %
  • 40-49: 34.17 %
  • 50-59: 38.33 %
  • 60+: 23.33 %

Severity if Hypothyroidism when taking Flexeril **:

  • least: 0.0 %
  • moderate: 100 %
  • severe: 0.0 %
  • most severe: 0.0 %

How people recovered from Hypothyroidism **:

  • while on drug: 0.0 %
  • after off the drug: 0.0 %
  • not yet: 100 %

Top conditions involved for these people *:

  • Pain (31 people)
  • Osteoporosis (18 people)
  • Muscle Spasms (18 people)
  • Hypertension (16 people)
  • Anxiety (12 people)

Top co-used drugs for these people *:

  • Synthroid (54 people)
  • Vioxx (43 people)
  • Neurontin (41 people)
  • Nexium (34 people)
  • Lasix (29 people)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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