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Review: could Gabapentin cause Serotonin syndrome?

Summary: Serotonin syndrome could be caused by Gabapentin, especially for people who are female, 60+ old, have been taking the drug for < 1 month, also take Levothyroxine sodium, and have Pain.

We study 36,656 people who have side effects while taking Gabapentin from FDA and social media. Among them, 146 have Serotonin syndrome. Find out below who they are, when they have Serotonin syndrome and more.

On Apr, 10, 2014: 36,743 people reported to have side effects when taking Gabapentin. Among them, 146 people (0.40%) have Serotonin Syndrome. They amount to 0.42% of all the 34,358 people who have Serotonin Syndrome on eHealthMe.

Trend of Serotonin syndrome in Gabapentin reports

Time on Gabapentin when people have Serotonin syndrome * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Serotonin syndrome50.00%25.00%25.00%0.00%0.00%0.00%0.00%

Age of people who have Serotonin syndrome when taking Gabapentin * :

0-12-910-1920-2930-3940-4950-5960+
Serotonin syndrome0.00%0.00%0.00%12.07%22.41%12.07%16.38%37.07%

Severity of Serotonin syndrome when taking Gabapentin ** :

leastmoderateseveremost severe
Serotonin syndrome0.00%100.00%0.00%0.00%

How people recovered from Serotonin syndrome ** :

n/a

Top conditions involved for these people * :

  1. Pain (41 people, 28.08%)
  2. Depression (26 people, 17.81%)
  3. Neuralgia (24 people, 16.44%)
  4. Contraception (12 people, 8.22%)
  5. Overweight (8 people, 5.48%)

Top co-used drugs for these people * :

  1. Levothyroxine sodium (30 people, 20.55%)
  2. Omeprazole (30 people, 20.55%)
  3. Clonazepam (27 people, 18.49%)
  4. Tramadol hcl (27 people, 18.49%)
  5. Lisinopril (23 people, 15.75%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Gabapentin, Serotonin syndrome

You can also:

On eHealthMe, Gabapentin (gabapentin) is often used for pain. Find out below the conditions Gabapentin is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

What is Gabapentin used for and how effective is it:

Other drugs that are used to treat the same conditions:

Could it be a symptom from a condition:

Drugs in real world that are associated with:

Could your condition cause it?

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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