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Review: could Gleevec cause Nephrolithiasis?

We study 20,251 people who have side effects while taking Gleevec from FDA and social media. Among them, 84 have Nephrolithiasis. Find out below who they are, when they have Nephrolithiasis and more.

Stay connected: get help anytime and anywhere for people who take Gleevec and have Nephrolithiasis >>>

Gleevec

Gleevec (latest outcomes from 20,434 users) has active ingredients of imatinib mesylate. It is often used in chronic myelogenous leukemia (cml).

Nephrolithiasis

Nephrolithiasis (calculi in the kidneys) (latest reports from 106,108 patients) has been reported by people with multiple sclerosis, osteoporosis, high blood pressure, rheumatoid arthritis, pain.

On Jul, 15, 2014: 20,250 people reported to have side effects when taking Gleevec. Among them, 84 people (0.41%) have Nephrolithiasis. They amount to 0.08% of all the 106,063 people who have Nephrolithiasis on eHealthMe.

Trend of Nephrolithiasis in Gleevec reports

Time on Gleevec when people have Nephrolithiasis * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ years
Nephrolithiasis18.18%45.45%18.18%0.00%9.09%9.09%0.00%

Gender of people who have Nephrolithiasis when taking Gleevec * :

FemaleMale
Nephrolithiasis22.79%77.21%

Age of people who have Nephrolithiasis when taking Gleevec * :

0-12-910-1920-2930-3940-4950-5960+
Nephrolithiasis0.00%0.00%46.05%1.32%7.89%17.11%15.79%11.84%

Severity of Nephrolithiasis when taking Gleevec ** :

n/a

How people recovered from Nephrolithiasis ** :

n/a

Top conditions involved for these people * :

  1. Prophylaxis (35 people, 41.67%)
  2. Chronic myeloid leukaemia (33 people, 39.29%)
  3. Gastrointestinal stromal tumour (10 people, 11.90%)
  4. Osteoporosis (10 people, 11.90%)
  5. Malignant soft tissue neoplasm (9 people, 10.71%)

Top co-used drugs for these people * :

  1. Methotrexate (35 people, 41.67%)
  2. Zantac (35 people, 41.67%)
  3. Mercaptopurine (35 people, 41.67%)
  4. Bactrim (35 people, 41.67%)
  5. Cyclophosphamide (35 people, 41.67%)

* Approximation only. Some reports may have incomplete information.

** Reports from social media are used.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (3 weeks ago):

  • Kreese on Jun, 11, 2011:

    I was diagnosed Type 2 diabetic late 2010 and started onn Medformin 250 mg twice a day. very strange that my blood sugars were normal afdter 1 week on the meds and continued to be normal even after having a none fasting blood sugar and A1C done, which were all normal as well.

    Recently I had kidney stones from hell and was rushed to the hospital after being on Medformin for 6 Months.

    Being in the pharmaceutcal field I am convinced that Medformin causes Kidney Stones. Drug companies do not report all side affects from clinical trials to the FDA, this I can tell you they use the data that is good for them to get their dug approved. I am sure that the numbers are higher for people developing kidney stones from Medformin.

    Reply

    Wil on Aug, 5, 2011:

    I have been on Metformin 250mg twice daily for about 7 months. My first ever kidney stone event occured at 5 months with a second event at 7 months. Metformin was the replacement for Avandia which I had taken for years without incident. I am 68 years old.

    Reply

    Kenneth Cruthis on Mar, 5, 2013:

    I am seventy years old and in pretty good health, I am borderline type two diabetic. My doctor prescribed Metphormin and within a week I was passing multiple small kidney stones and after about a week , still passing stones, then I quit for a couple of weeks and the stones subsided, then I started taking the drug again and the stones started back up again, now I have had a history of stones in the past but nothing as frequent as this. I started taking 2000 mg. of Calcium each day and haven't been bothered with stones in several years until I started taking Metphormin. This is the only Generic drug that I know of for non insulin dependent diabetes. I may try it again for another test. I have decided that my health is my reasonability with loosing weight, diet and exercise.

    Reply

    Wil on Mar, 6, 2013:

    UPDATE: August and September 2012 had Lithotripsy for two large stones. Also stopped Metformin after consultation with Dr and reevaluation of the need. next recheck due in May 2013

    Reply

    Jones60 on Jun, 18, 2014:

    I have my first ever stone after a 6 month stint on Metformin....Now Im wondering if I should stop taking this drug

    Reply

  • From this study (2 months ago):

  • Swollen lymph nodes were not present when started the treatment

    Reply

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On eHealthMe, Gleevec (imatinib mesylate) is often used for chronic myelogenous leukemia (cml). Find out below the conditions Gleevec is used for, how effective it is, and any alternative drugs that you can use to treat those same conditions.

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